Physiologically-based pharmacokinetic (PBPK) modeling and simulations [electronic resource] : principles, methods, and applications in the pharmaceutical industry / Sheila Annie Peters.
Publication details: Hoboken, N.J. : Wiley, c2011.Description: xvii, 430 p. : illISBN:- 9780470484067 (cloth)
- 9781118140383 (e-book)
- 615/.7 23
- RM301.5 .P48 2011eb
eBooks
Includes bibliographical references and index.
Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain.
Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries.