Chapter 1 The Influence of Microstructure on Neural Tissue Mechanics -- Chapter 2 Modeling a Collagenous Tissues Using Distributed Fiber Orientations -- Chapter 3 Emergent Behaviors in Cell Mechanics -- Chapter 4 Histomechanical Modeling of the Wall of Abdominal Aortic Aneurysm -- Chapter 5 The Biomechanics of Fat: From Tissue to a Cell Scale -- Chapter 6 Glaucoma and Structure-Based Mechanics of the Lamina Cribrosa at Multiple Scales -- Chapter 7 From Stress-Strain Relations to Formulation of Growth and Remodeling Theories: A Historical Reflection on Microstructurally-Motivated Constitutive Relations -- Chapter 8 Relationship Between Structure and Mechanics for Membranous Tissues -- Chapter 9 Structure-Function Relations in the Coronary Vasculature -- Chapter 10 Biomechanical Basis of Myocardium/Vessel Interaction: Implications for Patho-Physiology and Therapy -- Chapter 11 Microstructure-Based Constitutive Models for Coronary Artery Adventitia -- Chapter 12 Structural-Based Models of Ventricular Myocardium -- Chapter 13 Structure-Based Constitutive Model of Coronary Media -- Chapter 14 Biomechanics of the Cornea and Sclera -- Chapter 15 Mechanical Modeling of Skin -- Chapter 16 Undesirable Anisotropy in a Discrete Fiber Bundle Model of Fibrous Tissues --     Chapter 17 Structural Models as Applied to Engineered Tissue Scaffolds -- Chapter 18 Finite Element Implementation of Structural Models -- Chapter 19 A Microvascular Model in Skeletal Muscle Fascia -- Chapter 20 Network Approaches to the Mechanical Failure of Soft Tissues: Implications for Disease and Tissue Engineering.

This book portrays the commonality of tissue micro-structure that dictates physiological function in various organs (microstructure-function relation). Tissue and organ models are used to illustrate physiological functions based on microstructure. Fiber scale properties such as orientation and crimp are described in detail. Structurally-based constitutive models are given throughout the book, not only to avoid ambiguities in material characterization, but also to offer insights into the function, structure, and mechanics of tissue components. A statement of future directions of the field is also given, including how advancements, such as state-of-the-art computational modeling and optical measurements of tissue/cells structures, are taking structure-based modeling to the next level.  This book also: Provides a comprehensive view of tissue modeling across multiple systems Broadens readers’ understanding of state-of-the-art computational modeling and optical measurements of tissue/cells structures Describes in detail fiber scale properties such as orientation and crimp.