Online resource; title from PDF title page (EBSCO, viewed January 10, 2018)

Includes bibliographical references.

Front Cover; Myogenesis in Development and Disease; Copyright; Contents; Contributors; Preface; Chapter One: "What Did Maxwell's Equations Really Have to Do With Edison's Invention?": Addressing the Complexity; 1. Introduction; 2. The Innovation System Pipeline Leading to Clinical Intervention Creation; 3. The Relevance of Health Economics and Population Health in Decision-Making and the Complexity of a Degenerating Muscle; 4. The Price of Failure; 5. Concluding Comments; References; Further Reading; Chapter Two: The Muscle Stem Cell Niche in Health and Disease; 1. Introduction

2. The Perinatal MuSC Niche3. The Quiescent MuSC Niche; 4. The Regenerative MuSC Niche; 4.1. The Inflammatory Niche; 4.2. The Mitogenic Niche; 4.3. The Differentiative Niche; 5. The MuSC Niche in Aging; 6. The Pathologic MuSC Niche; 7. Targeting the Niche for Therapy; 8. Concluding Remarks; References; Chapter Three: Translational Control of the Myogenic Program in Developing, Regenerating, and Diseased Skeletal Muscle; 1. Introduction; 1.1. Regulation of Translation; 1.2. Myogenesis; 1.2.1. Cell Fate Choices by Multipotent Progenitors

1.2.2. Multiple Sequential Steps Define the Myogenic Program1.2.3. Establishment of the Muscle Stem Cell Pool; 2. MicroRNA Regulation of the Myogenic Program; 2.1. MicroRNA Regulation of Embryonic Myogenesis; 2.1.1. Dicer Mutants; 2.1.2. MicroRNA Regulation of Myogenic Determination; 2.1.3. MyomiRs; 2.2. MicroRNA Regulation of Quiescent Satellite Cells; 2.3. Intronic MicroRNAs Enforce the Activity of Host Genes Throughout Myogenesis; 2.4. MicroRNA Dysregulation in Muscle Disease; 2.5. Regulation of MicroRNA Activity With Long Noncoding RNAs; 2.6. Future Directions

3. Regulation of the Myogenic Program by RNA-Binding Proteins (RBPs)3.1. Cooperation Between MicroRNAs and RBP Regulation of Gene Expression; 4. Satellite Cells Are Regulated by Translational Control Mechanisms Impacting Global Protein Synthesis; 4.1. Regulation of Global Protein Synthesis; 4.2. The Phosphorylation of eIF2α Is a Translational Control Mechanism Responding to Various Cellular Stresses; 4.3. Regulation of Satellite Cells by mTorc1; 5. Concluding Remarks; Acknowledgments; References; Chapter Four: The Composition, Development, and Regeneration of Neuromuscular Junctions

1. Neuromuscular Junction Composition and Function2. NMJ Development and Maturation; 3. NMJ Regeneration; 4. NMJs and Diseases/Aging; 5. Conclusion and Future Directions; References; Chapter Five: Cellular Biomechanics in Skeletal Muscle Regeneration; 1. Introduction; 2. Matrix Regulation of Skeletal Muscle Regeneration; 2.1. Maintenance of Satellite Cell Quiescence; 2.2. Induction of Satellite Cell Activation; 2.3. Self-Renewal of Muscle Progenitor Cell Reserves; 2.4. Myogenic Commitment and Differentiation; 2.5. Migration of Myogenic Progenitor Cells

Myogenesis in Development and Disease, Volume 126, the latest volume in the Current Topics in Developmental Biology series, covers major topics of research in myogenesis, with a particular emphasis on regeneration and muscle disease. It includes contributions from an international board of authors, providing a comprehensive set of reviews.

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