This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, this latest edition is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. *Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components *Part II covers the organizational structure and cellular metabolism of bone and cartilage *Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease.

Section ToC -- PART I -- Components of the Organic Extracellular Matrix of Bone and Cartilage -- PART II -- Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage -- PART III -- Markers of Bone and Cartilage Metabolism.

Includes bibliographical references and index.

Structure, biosynthesis and gene regulation of collagens in cartilage and bone / Klaus von der Mark -- Fibrillogenesis and maturation of collagens / Simon P. Robins -- Vitamin K dependent proteins of bone and cartilage / Caren M. Gundberg and Satoru K. Nishimoto -- Noncollagenous proteins: glycoproteins and related proteins / Dick Heinegård, Pilar Lorenzo, and Tore Saxne -- Proteoglycans and glycosaminoglycans / Tim Hardingham -- Growth factors / Philippa Hulley, Graham Russell, and Peter Croucher -- Prostaglandins and proinflammatory cytokines / Lawrence G. Raisz and Joseph A. Lorenzo -- Integrins and other adhesion molecules / M.H. Helfrich and M.A. Horton -- Alkaline phosphatases / José Luis Millán -- Acid phosphatases / Helena Kaija [and others] -- Matrix proteinases / Ian M. Clark and Gillian Murphy -- Mineralization, structure and function of bone / Adele L. Boskey -- Bone structure and strength / Ego Seeman -- The cells of bone / Jane B. Lian and Gary S. Stein -- Signaling in bone / T. John Martin and Natalie A. Sims -- Parathyroid hormone: structure, function and dynamic actions / Lorraine A. Fitzpatrick and John P. Bilezikian -- Interaction of parathyroid hormone-related peptide with the skeleton / David Goltzman -- The vitamin D hormone and its nuclear receptor: mechanisms involved in bone biology / Geert Carmeliet [and others] -- Sex steroid effects on bone metabolism / David G. Monroe, Thomas C. Spelsberg, and S. Khosla -- Physiology of calcium and phosphate homeostasis / René Rizzoli and Jean-Philippe Bonjour -- The central control of bone remodelling / Paul A. Baldock [and others] -- New concepts in bone remodeling / David W. Dempster and Hua Zhou -- Products of bone collagen metabolism / Juha Risteli and Leila Risteli -- Supramolecular structure of cartilage matrix / Peter Bruckner -- Products of cartilage metabolism / Daniel-Henri Manicourt, Jean-Pierre Devogelaer, and Eugene J.-M.A. Thonar -- Fluid dynamics of the joint space and trafficking of matrix products / Peter A. Simkin.

Transgenic models of bone disease / Barbara E. Kream and John R. Harrison -- The role of genetic variation in osteoporosis / André G. Uitterlinden [and others] -- Measurement of calcium, phosphate and magnesium / Heinrich Schmidt-Gayk -- Measurement of parathyroid hormone / Harald Jüppner and Ghada El-Hajj Fuleihan -- New horizons for assessment of vitamin D status in man / Gary L. Lensmeyer, Neil Binkley, and Marc K. Drezner -- Measurement of biochemical markers of bone formation / Kim E. Naylor and Richard Eastell -- Measurement of biochemical markers of bone resorption / Marius E. Kraenzlin and Markus J. Seibel -- Variability in the measurement of biochemical markers of bone turnover / Tuan V. Nguyen, Christian Meier, and Markus J. Seibel -- Validation of biochemical markers of bone turnover / Kim Brixen and Erik Fink Eriksen -- Genetic markers of joint disease / Michel Neidhart, Renate E. Gay, and Steffen Gay -- Laboratory assessment of postmenopausal osteoporosis / Patrick Garnero and Pierre D. Delmas -- Monitoring anabolic treatment / John P. Bilezikian and Mishaela R. Rubin -- Monitoring of antiresorptive therapy / Christian Meier, Tuan V. Ngyen, and Markus J. Seibel -- Age-related osteoporosis and skeletal markers of bone turnover / Clifford J. Rosen -- Steroid-induced osteoporosis / Ian R. Reid -- Transplantation osteoporosis: biochemical correlates of pathogenesis and treatment / Carolina A. Moreira Kulak and Elizabeth Shane -- Secondary osteoporosis / Jean E. Mulder, Carolina A. Moreira Kulak, and Elizabeth Shane -- Osteomalacia and rickets / Marc K. Drezner -- Assessment of bone and joint diseases: renal osteodystrophy / Esther A. González, Ziyad Al Aly, and Kevin J. Martin -- Primary hyperparathyroidism / Shonni J. Silverberg, and John P. Bilezikian -- Paget's disease of bone / Andreas Grauer, Ethel Siris, and Stuart Ralston -- Metastatic bone disease / Jean-Jacques Body -- Rare bone diseases / Michael P. Whyte -- Osteogenesis imperfecta / Francis H. Glorieux and Frank Rauch -- Rheumatoid arthritis and other inflammatory joint pathologies / Steven R. Goldring and Mary B. Goldring -- Osteoarthritis and degenerative spine pathologies / Kristina Åkesson.

Print version record.

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