Sertoli cells assist in the production of sperm in the male reproductive system. This book provides a state-of-the-art update on the topic of sertoli cells and male reproduction. It addresses such highly topical areas as stem cells, genomics, and molecular genetics, as well as provides historical information on the discovery of this type of cell, and the pathophysiology of male infertility. * Presents the state-of-the-art research on topics such as stem cell research, transplantation and genomics * Includes contributions from leaders in the field, including several members of the National Academy of Science * Discusses the pathophysiology of male infertility * State-of-the-art chapters on current science advancements * Stands as the only current reference on the topic of sertoli cells.

Introduction. History of the Sertoli Cell Discovery; Perspective on the Function of Sertoli Cells; Structure of the Sertoli Cell. Sertoli Cell Development; Embryonic Sertoli Cell Differentiation; -- Sertoli Cell Biology in Fish and Amphibians; Sertoli Cell Biology in Seasonal Breeders; Sertoli Cell Function and Gene Expression; Sertoli Cell Gene Expression and Protein Secretion; Secretion of Regulatory Factors; Proteases and Protease Inhibitors; Sertoli Cell Endocrinology and Signal Transduction; FSH Regulation at the Molecular and Cellular Level; Mechanisms of Action and Function Effects; In Vivo FSH Actions; Sertoli Cell Endocrinology and Signal Transduction: Androgen Regulation; Thyroid Hormone Regulation of Sertoli Cell Development; The Transforming Growth Factor ́ (TGF́) Superfamily in Sertoli Cell Biology; Sertoli Cell Signal Tansduction (cAMP and JAK); Sertoli Cells Transcriptional Regulation; Transcription Factors in Sertoli Cells; Structure & Regulation of the FSH Receptor Gene; Sex Determination Genes in Sertoli Cells; Cell-Cell Interactions Involving Sertoli Cells; The Role of the Sertoli Cell in Spermatogonial Stem Cell Fate; Sertoli Cell-Somatic Cell Interactions; Sertoli Cell Lines; Sertoli Cell Pathophysiology; Sertoli Cell Toxicants; Conditions Affecting Sertoli Cells. Spermatogonial Stem Cells: Gonocyte Development; Hormones and Spermatogonial Development; Long-Term Cultures of Mammalian Spermatogonia; Transplantation.

Includes bibliographical references and index.

Print version record.

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