"Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals."-- Provided by publisher.

Includes bibliographical references and index.

Vol. 1. Strategies for plasmid DNA production in Escherichia coli / Eva Brand, Kathrin Ralla, and Peter Neubauer -- Advances in protein production technologies / Linda H.L. Lua and Yap Pang Chuan -- Releasing biopharmaceutical products from cells / Anton P.J. Middelberg -- Continuous chromatography (multicolumn countercurrent solvent gradient purification) for protein purification / Guido Strö̈hlein, Thomas Müller-Späth, and Lars Aumann -- Virus-like particle bioprocessing / Yap Pang Chuan, Linda H.L. Lua, and Anton P.J. Middelberg -- Therapeutic protein stability and formulation / Robert Falconar -- Production of PEGylated proteins / Conan J. Fee and Vinod B. Damodaran -- Affinity chromatography: historical and prospective overview / Laura Rowe, Graziella El Khoury, and Christopher R. Lowe -- Hydroxyapatite in bioprocessing / Frank Hilbrig and Ruth Freitag -- Monoliths in bioprocessing / Ales̆ Podgornik, Milos̆ Barut, Matjaz̆ Peterka, and Ales̆ S̆trancar -- Membrane chromatography for biopharmaceutical manufacturing / Omar M. Wahab -- Modeling and experimental model parameter determination with quality by design for bioprocesses / Christoph Helling and Jochen Strube.

Vol. 2. Biosensors in the processing and analysis of biopharmaceuticals / Sriram Kumaraswamy -- Proteomics toolkit: applications in protein biological production and method development / Glenwyn Kemp and Achim Treumann -- Science of proteomics: historical perspectives and possible role in human healthcare / Nawin Mishra -- Consistency of scale-up form bioprocess development to production / Stefan Junne, Arne Klingner, Dirk Itzeck, Eva Brand, and Peter Neubauer -- Systematic approach to optimization and comparability of biopharmaceutical glycosylation throughout the drug life cycle / Daryl L. Fernandes -- Quality and risk management in ensuring the virus safety of biopharmaceuticals / Andy Bailey -- Ensuring quality and efficiency of bioprocesses by the tailored application of process analytical technology and quality by design / Helmut Trautmann -- Bioprocess design and production technology for the future / Jochen Strube, Florian Grote, and Reinhard Ditz -- Integrated process design: characterization of process and product definition of design spaces / Richard Francis -- Evaluating and visualizing the cost-effectiveness and robustness of biopharmaceutical manufacturing strategies / Suzanne S. Farid -- Full plastics: consequent evolution in pharmaceutical biomanufacturing from vial to warehouse / Roland Wagner and Dethardt Müller -- BioSMB[TM] technology: continuous countercurrent chromatography enabling a fully disposable process / Marc Bisschops -- Single-use technology: opportunities in biopharmaceutical processes / Maik W. Jornitz, Detlev Szarafinski, and Thorsten Peuker -- Single-use biotechnologies and modular manufacturing environments invite paradigm shifts in bioprocess development and biopharmaceutical manufacturing / Alfred Luitjens, John Lewis, and Alain Pralong.

John Wiley and Sons Wiley eBooks