Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed March 9, 2016).

Includes bibliographical references at the end of each chapters and index.

Front Cover; Genes, Environment and Alzheimer's Disease; Copyright Page; Contents; List of Contributors; Foreword; Preface; Introduction; 1 Molecular Mechanisms of Learning and Memory; From Plato's Wax Tablet to Genes; Memory Processes; Brain Structures Underlying Memory Processes; Cellular Basis of Memory; The Role of CREB in Memory; Pathways Activating CREB; HDACs/HATs Role in Gene Transcription; References; 2 When Cognitive Decline Becomes Pathology: From Normal Aging to Alzheimer's Disease; Models of Cognitive Decline in Healthy Aging

Distinguishing AD-Associated Cognitive Decline from Normal AgingDistinguishing Preclinical AD from Normal Aging with Event-Related Potentials (ERPs); Memory Deficits in Preclinical AD; Deficits in Associative Memory; Deficits in Pattern Separation; Deficits in Recollection and Familiarity; Deficits in Prospective Memory; Deficits in Remote Memory; Deficits in Working Memory; Asymmetric Cognitive Decline in Preclinical AD; Summary and Conclusions; References; 3 Adult Neurogenesis and Cognitive Function: Relevance for Disorders Associated with Human Aging; Introduction

Identification and Characterization of Adult NeurogenesisDevelopment and Maturation of Adult-Born Neurons; Adult Mammalian Hippocampal Circuitry; Factors Affecting Adult Neurogenesis; Neurogenic Niche; Stress; Aging; Environmental Enrichment, Physical Activity, and Diet; Antidepressants and Mood-Stabilizing Treatments; Proposed Functions of Adult Neurogenesis; Pattern Separation; Other Aspects of Spatial and Contextual Memory; Regulation of Mood and the HPA-Axis; Neurogenesis, Hippocampal Dysfunction, and Alzheimer's Disease; Proteins Linked to FAD Regulate Neurogenesis

Methodologies for Studying Adult NeurogenesisLabeling Dividing and Maturing Cells; Manipulating Neurogenesis in Rodents; Human Technologies; Conclusion; References; I. Hallmarks and Genetic Forms of AD; 4 The Amyloid β Precursor Protein and Cognitive Function in Alzheimer's Disease; Introduction; The APP Gene and Its Homologs; The APP Protein, Its Domains, and Its Proteolytic Fragments; Intracellular Trafficking and Processing of APP; Cholesterol and APP Processing; APP-Interacting Proteins: Signal Transduction and Processing; Interactors with the YENPTY Motif

Low-Density Lipoprotein ReceptorsFunctions of APP; Neurogenesis: Embryonic and Adult; Neurite Outgrowth; Axonal Transport; Synaptic Formation and Function; Transcription Factor; Metal Binding/Redox; Does Aβ Have a Function?; APP Knockout Mice; APP and AD; Disrupted Axonal Transport; Disrupted Neurogenesis; Altered APP Processing/Translocation; Altered Signal Transduction; References; 5 Molecular Pathways in Alzheimer's Disease and Cognitive Function: New Insights into Pathobiology of Tau; Introduction; Normal Production and Function of Tau; Pathogenic Tau; Tau-Mediated Neuronal Deficits

This volume explores the interplay between genetic and environmental risk factors in the induction of cognitive decline and the development of dementia-related diseases such as Alzheimer's.

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