Biology and engineering of stem cell niches / edited by Ajaykumar Vishwakarma, Jeffrey M. Karp.
Publisher: London, United Kingdom : Academic Press is an imprint of Elsevier, 2017Description: 1 online resourceContent type:- text
- computer
- online resource
- 9780128027561
- 0128027568
- QH588.S83
eBooks
Vendor-supplied metadata.
880-01 Front Cover; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; Copyright; Contents; List of Contributors; Foreword; 1 -- Biology of Stem Cell Niches and Molecular Mechanisms; 1 -- The Need to Study, Mimic, and Target Stem Cell Niches; 1. INTRODUCTION; 1.1 The Stem Cell Niche in Health and Disease; 1.2 Components of Stem Cell Niche; 2. BIOLOGY OF THE STEM CELL NICHE; 2.1 Behavior of Stem Cells: Hierarchical Versus Stochastic Model; 2.2 Embryonic and Adult Stem Cell Niches; 3. BIOCHEMICAL AND BIOPHYSICAL REGULATION OF STEM CELL BEHAVIOR.
3.1 Extracellular Matrix and Biochemical Cues3.2 Soluble Growth Factors and Ligands; 3.3 Physical Cues and Matrix Mechanics; 3.4 Oxygen and Metabolism; 3.5 Immune Cells, Inflammation, and Immunomodulation; 4. MIMICKING THE STEM CELL NICHE: BIOENGINEERING TOOLS AND TECHNIQUES; 5. BIOENGINEERING SPECIALIZED ARTIFICIAL STEM CELL NICHES FOR CLINICAL THERAPIES; References; 2 -- Harnessing the Biology of Stem Cells' Niche; 1. INTRODUCTION; 2. COMPONENTS OF THE STEM CELL NICHE; 2.1 Cellular Components; 2.2 Noncellular Components; 3. INTEGRATIVE NETWORKS REGULATING THE NICHE.
4. DISTINCT NICHES FOR DIFFERENT STAGES OF DIFFERENTIATION5. NEOPLASTIC TRANSFORMATION AND DISTURBANCE OF THE TISSUE ECOSYSTEM; 6. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; References; 3 -- Pluripotent Stem Cell Microenvironment; 1. INTRODUCTION; 2. PLURIPOTENT CELL MICROENVIRONMENT IN THE EARLY MAMMALIAN EMBRYO; 2.1 Lineage Specification in the Preimplantation Embryo; 2.2 Role of Extraembryonic Cells in Development of the Pluripotent Cells; 2.2.1 Interactions Between Inner and Outer Blastomeres During the ICM Versus TE Specification and Associated Signals.
2.2.2 Cellular Interplay Between the PrE and the Epiblast3. MICROENVIRONMENT OF PLURIPOTENT STEM CELLS IN VITRO; 3.1 Derivation of Embryonic Stem Cells; 3.2 Cellular Heterogeneity in Mouse ESC Cultures; 3.3 Epigenetic Mechanisms Underlying Metastable States of Mouse ESCs; 3.4 Heterogeneity of Human ESC Culture; 3.5 Functional and Epigenetic Distinctions Between Human ESC Subfractions; 3.6 Regulatory Niche in Human ESC Culture; 4. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; Acknowledgment; References; 4 -- Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling.
Includes index.
Elsevier ScienceDirect All Books