Includes bibliographical references and index.

Neuroglial Communication in White Matter: The "Nodal Synapse"Adrenergic Mechanisms in White Matter; Adrenergic Signaling in White Matter Physiology; Adrenergic Signaling in White Matter Pathology; Adrenergic Signaling Regulates Blood Flow; Conclusions; Abbreviations; References; 4 Role for Astroglial [alpha]1-Adrenergic receptors in Glia-Neuron Communications and Aging-Related Metaplasticity in the Neocortex; Introduction; Role for Astroglia in Brain Signaling and Metaplasticity; Astrocytic Ca2+ Signaling: Specific Role for Adrenergic Receptors

Adrenergic Activation Triggers Phasic Ca2+ and Tonic cAMP/PKA Responses in Cultured AstrocytesSimultaneous Activation of [alpha]- and [beta]-ARs Potentiates Ca2+ and cAMP/PKA Responses in Astrocytes; Characteristics of Adrenergic Ca2+ Signaling in Astrocytes In Situ and In Vivo; Adrenergic Excitability and Availability of Glycogen-Derived Cytosolic Glucose in Astrocytes; Adrenergic Excitability and Astrocyte Morphologic Plasticity; [beta]-Adrenergic Activation and Stellation of Astrocytes; Adrenergic Activation and Astrocyte Morphology In Vivo: Prevention of CNS Cellular Edema; Conclusions; Abbreviations

Adrenergic Receptors Induce the Release of Gliotransmitters From Neocortical AstrocytesAge- and Environment-Related Alterations in Astroglial Adrenergic Signaling; Astroglial [alpha]1-Adrenergic Receptors Modulate Synaptic Transmission and Plasticity in the Neocortex; Summary and Perspectives; Abbreviations; References; 5 Adrenergic Ca2+ and cAMP Excitability: Effects on Glucose Availability and Cell Morphology in Astrocytes; Introduction; Adrenergic Modulation of Cytosolic Ca2+ and cAMP Excitability in Cultured Astrocytes

[beta]-Adrenergic Signaling PathwaysSignaling Pathways for Astrocytic [alpha]-Adrenergic Receptor Subtypes; Metabolic Effects of [alpha]- and [beta]-Adrenergic Stimulation of Astrocytes; Glucose Uptake; Glucose Metabolism; Glycogen Turnover; Importance of Glycogen Turnover for Brain Function; [beta]1-Adrenergic Stimulation of the Astrocytic Na+,K+-ATPase; Importance of Adrenergic Stimulation During Culturing of Astrocytes; Conclusions; Abbreviations; References; 3 White Matter Astrocytes: Adrenergic Mechanisms; Introduction; White Matter Glia Ensure Rapid Neuronal Signaling Over Long Distances

Front Cover; Noradrenergic Signaling and Astroglia; Copyright Page; Contents; List of Contributors; Preface; Acknowledgments; 1 Locus Coeruleus Noradrenergic Neurons and Astroglia in Health and Disease; Locus Coeruleus: Anatomy and Pathophysiology; Astroglia and Neurodegeneration; Presymptomatic Stage of Neurodegeneration Involves Astrogliosis; Dysregulation of Astrocytic Vesicle Dynamics in Neurodegeneration; Conclusions; Abbreviations; Acknowledgements; References; 2 Astroglial Adrenergic Receptor Signaling in Brain Cortex; Astrocytic and Neuronal Adrenergic Receptor Expression

Includes index.

Print version record.

"Noradrenergic Signaling and Astroglia integrates what is known about the active role of astroglia in the locus coeruleus-noradrenergic system and outlines the most recent advances in the field. It discusses the molecular mechanisms underlying norepinephrine-induced receptor activation in astroglia, cellular metabolism and CNS energy provision, in vitro, ex vivo, and in vivo models, gliosignalling and neuronal activity, and astroglial networks, gap junctions, and morphological plasticity. The book also addresses the role of astroglial adrenergic receptor activation in memory formation, cognition, regulation of sleep homeostasis, and lastly in neurological disorders, including trauma (cellular edema), neurodegeneration (Alzheimer's disease), and neuroinflammation (multiple sclerosis). Noradrenergic Signaling and Astroglia is a valuable source of new knowledge for a wide audience, including graduate students, post-doctoral fellows, and researchers in neuroscience, life sciences, and the biological and biomedical sciences"-- Publisher's web site.

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