Companion v. to Brenner & Rector's the kidney / edited by Barry M. Brenner. 7th ed. c2004.

Includes bibliographical references and index.

Sect. 1. Background and history. A history of hypertension treatment -- The National High Blood Pressure Education Program -- Epidemiology of hypertension -- sect. 2. Pathophysiology. Pathophysiology of hypertension -- Blood pressure genetics -- The sympathetic nervous system in acute and chronic blood pressure elevation -- Environmental and psychosocial stress in hypertension onset and progression -- Renin -- Angiotensin-converting enzymes: properties and function -- Angiotensin-(1-7) -- The angiotensin receptors: AT₁ and AT₂ -- Aldosterone and mineralocorticoids -- The role of insulin resistance and compensatory hyperinsulinemia in patients with essential hypertension -- Remodeling of resistance arteries in hypertension -- Clinical applications of arterial stiffness in hypertension -- Endothelium in hypertension: nitric oxide.

Endothelin in hypertension -- Natriuretic peptides -- Vasodilator peptides: CGRP, substance P, and adrenomedullin -- The Kallikrein-Kinin System as a regulator of cardiovascular and renal function -- sect. 3. Target organ damage/cardiovascular events. The concept of total risk -- New interpretations of blood pressure: the importance of pulse pressure -- Coronary atherosclerotic sequelae of hypertension -- Left ventricular hypertrophy, congestive heart failure, and coronary flow reserve abnormalities in hypertension -- Renal protection in chronic kidney disease -- sect. 4. Diagnosis. Initial evaluation and follow-up assessment -- Prognostic and diagnostic value of ambulatory blood pressure monitoring -- White-coat hypertension -- sect. 5. Treatment: general considerations. The blood pressure lowering treatment trialists' collaboration (BPLTTC).

The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) -- The LIFE study -- The VALUE trial -- Main results from VALUE -- Clinical outcome trials of hypertension with angiotensin receptor blockers -- ACE inhibitor trials: effects in hypertension -- Critical assessment of hypertension guidelines -- Current prescribing practices -- Calcium channel blockers: controversies, lessons, and outcomes -- Nursing clinics in the management of hypertension -- Community outreach -- Medication adherence for antihypertensive therapy -- sect. 6. Diet and nutrition. Diet: micronutrients -- Dietary approaches to hypertension management: the DASH studies -- Obesity and hypertension: impact on the cardiovascular and renal systems -- Alcohol and hypertension -- Obesity in hypertension: the role of diet and drugs -- Exercise and hypertension.

Sect. 7. Pharmacologic treatment. Initial choices in the treatment of hypertension -- Pharmacokinetics of antihypertensive drugs -- Fixed combination antihypertensive therapy -- Chronotherapeutics in the treatment of hypertension -- sect. 8. Comorbid conditions and special populations in hypertension. Diabetes mellitus and the cardiovascular metabolic syndrome: reducing cardiovascular and renal events -- Hypertension in patients on renal replacement therapy -- Ischemic heart disease in hypertension -- Hypertension in the elderly -- Management of hypertension in Black populations -- Hypertension in pregnancy -- Hypertension in children -- Resistant hypertension -- Orthostatic hypotension and autonomic dysfunction syndromes.

Sect. 9. Individual drug classes. How antihypertensive drugs get approved in the United States -- Diuretics: mechanisms of action -- [beta]-adrenergic blockers -- [alpha]-adrenoceptor blockers -- Angiotensin-converting enzyme inhibitors -- Calcium antagonists -- Angiotensin II receptor antagonists -- Direct-acting smooth muscle vasodilators and adrenergic inhibitors -- Endothelin antagonists -- Mineralocorticoid receptor antagonists -- Vasopeptidase inhibitors -- Renin inhibitors -- sect. 10. Secondary hypertension. Obstructive sleep apnea and hypertension -- Renovascular hypertension: diagnosis and treatment -- Adrenal cortex hypertension -- Phoechromocytoa: detection and management -- Anesthesia and hypertension -- Management of hypertensive emergencies and urgencies -- Aggressive blood pressure targets; developing effective algorithms.

The revised and updated 2nd Edition provides a logical, practical framework for managing patients with hypertension. Today's leading experts discuss all aspects of the field--from pathophysiology, pharmacological treatments, and lifestyle modifications to secondary hypertension and cardiovascular complications. Assesses the risks of specific pharmacological treatments * offers expert analysis of recent clinical trials * and providesDelivers strategies for managing patients with comorbid conditions such as diabetes, renal disease, and ischemic heart disease. Explains the role of vascular biology in the pathogenesis of hypertension.

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