The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field): * Initiation: Extracellular and Membrane Events * Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation * Events in Intracellular Compartments * Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field! * Contains approximately 470 articles * Provides well-organized sections on each essential area in signaling * Includes discussion on everything from ligand/receptor interactions to organ/organism responses * Extremely user-friendly.

Cell Signaling -- Yesterday, Today and Tomorrow -- Initiation: Extracellular and Membrane Events -- Molecular Recognition -- Vertical Receptors -- Horizontal Receptors -- Membrane Proximal Events -- Transmission: Effectors and Cytosolic Events -- Protein Phosphorylation -- Transmission: Effectors and Cytosolic Events -- Calcium Mobilization -- Lipid-Derived Second Messengers -- Protein Proximity Interactions -- Cyclic Nucleotides -- G Proteins -- Developmental Signaling -- Nuclear Responses: Gene Expression and Translation -- Nuclear Receptors -- Transcription Factors -- Damage/Stress Responses -- Translational Control -- Events in Intracellular Compartments -- Cell-Cell and Cell-Matrix Interactions.

Includes bibliographical references and index.

pt. I. Initiation: extracellular and membrane events -- pt. II. Transmission: effectors and cytosolic events -- pt. III. Nuclear and cytoplasmic events: transcriptional and post-transcriptional regulation -- pt. IV. Events in intracellular compartments -- pt. V. Cell-cell and cell-matrix interactions.

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