000			03592nam a22004935i 4500
001			978-0-387-27445-4
003			DE-He213
005			20160614135109.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387274454 _9978-0-387-27445-4
024	7		_a10.1007/b139083 _2doi
049			_aAlfaisal Main Library
050		4	_aQH573-671
072		7	_aPSF _2bicssc
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aRich, Tina. _eauthor.
245	1	0	_aToll and Toll-Like Receptors: An Immunologic Perspective _h[electronic resource] / _cby Tina Rich.
264		1	_aBoston, MA : _bSpringer US, _c2005.
300			_aX, 218 p. 76 illus., 6 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMolecular Biology Intelligence Unit
505	0		_aThe Function of Toll-Like Receptors -- Structures and Motifs Involved in Toll Signaling -- “Supramolecular” Activation Clusters in Innate Immunity -- Interleukin-1 Receptor/Toll-Like Receptor Signaling -- Virus Induced Signaling to Initiate the Interferon Mediated Anti-Viral Host Response -- The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling -- Pathogen Avoidance Using Toll Signaling in C. elegans -- Forward Genetic Analysis of TLR Pathways -- Agonists of Toll-Like Receptor 9.
520			_aToll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ­ ing it as a ^^MddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in "Structures and Motifs Involved in Toll Signaling".
650		0	_aLife sciences.
650		0	_aImmunology.
650		0	_aCell biology.
650	1	4	_aLife Sciences.
650	2	4	_aCell Biology.
650	2	4	_aImmunology.
655		7	_aElectronic books. _2local
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780306482373
830		0	_aMolecular Biology Intelligence Unit
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/b139083
912			_aZDB-2-SBL
942			_2lcc _cEBOOKS
999			_c243344 _d243344