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001 978-0-387-27530-7
003 DE-He213
005 20160614135109.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387275307
_9978-0-387-27530-7
024 7 _a10.1007/0-387-27530-4
_2doi
049 _aAlfaisal Main Library
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aNaveh-Many, Tally.
_eauthor.
245 1 0 _aMolecular Biology of the Parathyroid
_h[electronic resource] /
_cby Tally Naveh-Many.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aXIV, 199 p. 71 illus., 5 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMolecular Biology Intelligence Unit
505 0 _aDevelopment of Parathyroid Glands -- Parathyroid Hormone, from Gene to Protein -- Toward an Understanding of Human Parathyroid Hormone Structure and Function -- The Calcium Sensing Receptor -- Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate -- In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene -- Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D -- Vitamin D Analogs for the Treatment of Secondary Hyperparathyroidism in Chronic Renal Failure -- Parathyroid Gland Hyperplasia in Renal Failure -- Molecular Mechanisms in Parathyroid Tumorigenesis -- Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism -- Genetic Causes of Hypoparathyroidism -- Skeletal and Reproductive Abnormalities in Pth-Null Mice.
520 _aaintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu­ M lar calcium levels, by acting on bone, kidney and intestine. The recent intro­ duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper­ plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres­ sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha­ nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para­ thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex­ pression to its intracellular processing and the sequences in the gene control­ ling its transcription as well as those regulating mRNA processing, stability and translation are described.
650 0 _aMedicine.
650 0 _aMolecular biology.
650 0 _aEndocrinology.
650 0 _aNephrology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aNephrology.
650 2 4 _aEndocrinology.
655 7 _aElectronic books.
_2local
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780306478475
830 0 _aMolecular Biology Intelligence Unit
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/0-387-27530-4
912 _aZDB-2-SBL
942 _2lcc
_cEBOOKS
999 _c243353
_d243353