000 03467nam a22004935i 4500
001 978-3-540-28902-9
003 DE-He213
005 20160614135140.0
007 cr nn 008mamaa
008 100301s2005 gw | s |||| 0|eng d
020 _a9783540289029
_9978-3-540-28902-9
024 7 _a10.1007/3-540-28902-X
_2doi
049 _aAlfaisal Main Library
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
245 1 0 _aDeciphering Growth
_h[electronic resource] /
_cedited by Jean-Claude Carel, Paul A. Kelly, Yves Christen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _aXIII, 155 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aResearch and Perspectives in Endocrine Interactions
505 0 _aEvolutionary Trends in Body Size -- Sexual Dimorphism in the Growth of Homo sapiens: Facts, Inferences and Speculation -- Genetic Control of Size at Birth -- The GH/IGF-1 Axis: Insights from Animal Models -- Downstream Mechanisms of Growth Hormone Action -- Growth Hormone Receptor Signaling and Differential Actions in Target Tissues Compared to IGF-I -- IGF-I and Brain Growth: Multifarious Effects on Developing Neural Cells and Mechanisms of Action -- IGF-I Deficiency: Lessons from Human Mutations -- Putting IGF-I Biology into a Clinical Perspective -- IGF Resistance: The Role of the Type 1 IGF Receptor -- The Importance of the National Cooperative Growth Study (NCGS) -- Why we are Treating Children with Growth Hormone: Lessons from the French Registry.
520 _aGrowth is a complex process that is essential to life. Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. In mammals, the major factors involved in the regulation of body growth are known: insulin-like growth factors (IGF) are key regulators of somatic growth. Growth hormone (GH), secreted by the pituitary gland, directly regulates circulating levels of IGF-I, which is the major coordinator of spatio-temporal growth of the organism. In humans, growth involves a number of specific characteristics not found in other species. These include rapid intrauterine growth, deceleration just after birth, a mid-childhood growth spurt, a second deceleration before puberty, an adolescent growth spurt, and finally full statural growth, which is seen somewhat later. The combined knowledge concerning the endocrine and paracrine aspects of growth have led to the introduction of treatment regimens, most effective in GH-deficient children.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
655 7 _aElectronic books.
_2local
700 1 _aCarel, Jean-Claude.
_eeditor.
700 1 _aKelly, Paul A.
_eeditor.
700 1 _aChristen, Yves.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540261926
830 0 _aResearch and Perspectives in Endocrine Interactions
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/3-540-28902-X
912 _aZDB-2-SBL
942 _2lcc
_cEBOOKS
999 _c244973
_d244973