000			04834nam a22004695i 4500
001			978-1-59745-035-5
003			DE-He213
005			20160614135353.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9781597450355 _9978-1-59745-035-5
024	7		_a10.1007/978-1-59745-035-5 _2doi
049			_aAlfaisal Main Library
050		4	_aRC254-282
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
245	1	0	_aCancer Drug Resistance _h[electronic resource] / _cedited by Beverly A. Teicher.
264		1	_aTotowa, NJ : _bHumana Press, _c2006.
300			_aXVI, 617 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Drug Discovery and Development
505	0		_aPhysiological Resistance -- The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors -- Influence of Tumor pH on Therapeutic Response -- Tumor Oxygenation and Treatment Response -- Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance -- PET Imaging of Response and Resistance to Cancer Therapy -- Biological Resistance -- Cancer Stem Cells Implications for Development of More Effective Therapies -- Therapeutic Resistance in Leukemia -- Tumor Site Implantation and Animal Model Selection in Oncology -- In Vivo Resistance -- Characteristics of the Metastatic Phenotype -- The Microenvironment and Drug Resistance -- Biochemical Resistance -- Glutathione and Glutathione S-Transferases in Drug Resistance -- Metallothioneins in Drug Resistance -- Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors -- New and Revised Concepts in Multidrug Resistance -- Cisplatin Resistance -- Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters -- Resistance To Taxanes -- CpG Island Methylation and Drug Resistance -- De Novo and Acquired Resistance to Antitumor Alkylating Agents -- Resistance to Antiangiogenic Agents -- The Role of Hormones, Growth Factors, and Oncogenes -- Resistance to Antiestrogens -- Mechanisms of Glucocorticoid Actions and Resistance in Multiple Myeloma -- Herceptin Resistance -- Role of TGF-? in Tumor Progression and Metastasis -- p53-Based Immunotherapy of Cancer -- Response and Resistance to Ionizing Radiation -- Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance -- Clinical Aspects of Resistance -- Cancer Chemotherapy -- Molecular Profiling in Breast Cancer -- Tumor Immune Escape Mechanisms.
520			_aAs genomic techniques gradually reveal the ability of malignant cells to respond to chemical and biological insults with remarkable flexibility of phenotype, it becomes clear that much remains to be done to control and eliminate such cells. In Cancer Drug Resistance, leading scientists from the best academic institutions and industrial laboratories summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to a wide variety of anticancer therapeutics, as well as suggest new approaches to the biology of drug resistance that may afford new therapeutic opportunities. The authors review physiological resistance based tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin®. Authoritative and insightful, Cancer Drug Resistance offers basic and clinical investigators a state-of-the-art synthesis of the many faceted research now available on the biology and genetics of tumor resistance, as well as exciting new approaches to its prevention and eradication.
650		0	_aMedicine.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
655		7	_aElectronic books. _2local
700	1		_aTeicher, Beverly A. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588295309
830		0	_aCancer Drug Discovery and Development
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-1-59745-035-5
912			_aZDB-2-SME
942			_2lcc _cEBOOKS
999			_c247355 _d247355