000			03979nam a22005655i 4500
001			978-3-540-35109-2
003			DE-He213
005			20160614135727.0
007			cr nn 008mamaa
008			100301s2007 gw | s |||| 0|eng d
020			_a9783540351092 _9978-3-540-35109-2
024	7		_a10.1007/978-3-540-35109-2 _2doi
049			_aAlfaisal Main Library
050		4	_aRM1-950
072		7	_aMMG _2bicssc
072		7	_aMED071000 _2bisacsh
082	0	4	_a615 _223
245	1	0	_aConditional Mutagenesis: An Approach to Disease Models _h[electronic resource] / _cedited by Robert Feil, Daniel Metzger.
246	3		_aWith contributions by numerous experts
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2007.
300			_aXII, 532 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aHandbook of Experimental Pharmacology, _x0171-2004 ; _v178
505	0		_aTools for Conditional Mutagenesis -- Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases -- Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome -- Tetracycline-Controlled Genetic Switches -- Novel Gene Switches -- Improved Embryonic Stem Cell Technologies -- Gene Trap Mutagenesis -- RNA Interference in Mice -- Viral Vectors: A Wide Range of Choices and High Levels of Service -- Conditional Mutagenesis by Cell-Permeable Proteins: Potential, Limitations and Prospects -- Examples of Conditional Disease Models -- Analysis of Mouse Development with Conditional Mutagenesis -- Conditional Mouse Models of Cancer -- Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease Models -- Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory -- A Novel Conditional Knockout Strategy Applied to Serotonin Receptors -- Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopathy -- Animal Models in Cardiovascular Diseases: New Insights from Conditional Models -- Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders -- Conditional Mouse Models to Study Developmental and Pathophysiological Gene Function in Muscle -- Analysis of Calcium Channels by Conditional Mutagenesis -- Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins -- Contribution of Targeted Conditional Somatic Mutagenesis to Deciphering Retinoid X Receptor Functions and to Generating Mouse Models of Human Diseases.
520			_aLeading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aMolecular biology.
650		0	_aPharmacology.
650		0	_aMedical biochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aMolecular Medicine.
650	2	4	_aHuman Genetics.
650	2	4	_aMedical Biochemistry.
655		7	_aElectronic books. _2local
700	1		_aFeil, Robert. _eeditor.
700	1		_aMetzger, Daniel. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540351085
830		0	_aHandbook of Experimental Pharmacology, _x0171-2004 ; _v178
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-540-35109-2
912			_aZDB-2-SBL
942			_2lcc _cEBOOKS
999			_c251119 _d251119