000			04079nam a22004815i 4500
001			978-3-540-78771-6
003			DE-He213
005			20160614140222.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540787716 _9978-3-540-78771-6
024	7		_a10.1007/978-3-540-78771-6 _2doi
049			_aAlfaisal Main Library
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aShakibaei, Mehdi. _eauthor.
245	1	0	_aDiverse Roles of Integrin Receptors in Articular Cartilage _h[electronic resource] / _cby Mehdi Shakibaei, Constanze Csaki, Ali Mobasheri.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aVII, 62 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Anatomy Embryology and Cell Biology, _x0301-5556 ; _v197
505	0		_aIntroduction -- Integrins - multifunctional adhesion molecules -- Integrin structure-function relationships -- Structure of integrins -- EGF domains in ß1-integrins -- Integrins in articular cartilage -- Monolayer cultures -- High density (organoid-) cultures -- Concluding remarks -- Acknowledgements -- References -- Subject index.
520			_aIntegrins belong to an evolutionary conserved family of adhesion molecules with important biological functions throughout the animal kingdom. They are heterodimeric glycoproteins involved in cell-cell and cell-matrix adhesion and communication. Physiologically they function as intra- and extracellular signalling molecules in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic spread of tumor cells. Integrin beta 1 (ß1-integrin) is a multi-functional member of the integrin superfamily and is an integral protein involved in cell-matrix adhesion, cell signalling, cellular defense, cell adhesion, protein binding, protein heterodimerization and receptor-mediated activity. The ß1-integrin family of cell surface receptors appears to play a major role in mediating cell-extracellular matrix interactions that are important in regulating these fundamental processes. ß1-integrins are important adhesion molecules that are highly expressed in articular chondrocytes where they bind to extracellular matrix molecules including fibronectin, laminin, and fibrillar collagens. In addition to mediating cell adhesion, members of the ß1 subfamily of integrins contribute to the organisation of the cytoskeleton and activate numerous intracellular signal transduction pathways. Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
650		0	_aMedicine.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
655		7	_aElectronic books. _2local
700	1		_aCsaki, Constanze. _eauthor.
700	1		_aMobasheri, Ali. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540787709
830		0	_aAdvances in Anatomy Embryology and Cell Biology, _x0301-5556 ; _v197
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-540-78771-6
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