000 04120nam a22004815i 4500
001 978-94-017-7380-5
003 DE-He213
005 20160615101826.0
007 cr nn 008mamaa
008 151119s2015 ne | s |||| 0|eng d
020 _a9789401773805
_9978-94-017-7380-5
024 7 _a10.1007/978-94-017-7380-5
_2doi
049 _aAlfaisal Main Library
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aIntercellular Communication in Cancer
_h[electronic resource] /
_cedited by Mustapha Kandouz.
250 _a1st ed. 2015.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2015.
300 _aVIII, 366 p. 37 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Contributors.- Beyond the channel: Role of connexins in regulating normal and cancerous processes in the mammary gland.-     Connexins: Bridging the gap between the tumor microenvironment and cancer cell communication in brain tumors -- MicroRNA and Gap Junctions in Glioblastoma cells: Implications for cellular therapy.- Dynamic regulation of adherens junctions: implication in cell differentiation and tumor development -- Cadherin-based cell-cell adhesions: adhesion structure, signalling and computational modeling.- E-cadherin/catenin complex modulations in human oral cancer.-      Tumor-derived exosomes in metastasis signaling and implications.-      Tunneling Nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer.- Cell-Cell Fusion, Chemotaxis and Metastasis.- Role of the family of Ephs and Ephrins in non-junctional cell-cell communication in cancer.- Computational approaches to modeling of molecular interactions in multicellular systems.- Contact Normalization or Escape from the Matrix.- Intercellular communication, the tumor microenvironment, and tumor progression.- Index.
520 _aCells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aLife sciences.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aLife Sciences, general.
655 7 _aElectronic books.
_2local
700 1 _aKandouz, Mustapha.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789401773799
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-94-017-7380-5
912 _aZDB-2-SBL
942 _2lcc
_cEBOOKS
999 _c267782
_d267782