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001			978-1-4614-3209-8
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008			140324s2014 xxu| s |||| 0|eng d
020			_a9781461432098 _9978-1-4614-3209-8
024	7		_a10.1007/978-1-4614-3209-8 _2doi
049			_aAlfaisal Main Library
050		4	_aRE1-994
072		7	_aMJQ _2bicssc
072		7	_aMED063000 _2bisacsh
082	0	4	_a617.7 _223
245	1	0	_aRetinal Degenerative Diseases _h[electronic resource] : _bMechanisms and Experimental Therapy / _cedited by John D. Ash, Christian Grimm, Joe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail, Catherine Bowes Rickman.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014.
300			_aLXI, 862 p. 188 illus., 187 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v801
520			_aThis book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012).  A majority of those who will speak and present posters at the meeting will contribute to this volume.  The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70.  The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them.  Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field.   The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.   While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2010.  These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials.   The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general.  It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS.  Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2010 meeting and included in the proposed volume.  We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aGene therapy.
650		0	_aNeurosciences.
650		0	_aGeriatrics.
650		0	_aOphthalmology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOphthalmology.
650	2	4	_aNeurosciences.
650	2	4	_aGeriatrics/Gerontology.
650	2	4	_aHuman Genetics.
650	2	4	_aGene Therapy.
655		7	_aElectronic books. _2local
700	1		_aAsh, John D. _eeditor.
700	1		_aGrimm, Christian. _eeditor.
700	1		_aHollyfield, Joe G. _eeditor.
700	1		_aAnderson, Robert E. _eeditor.
700	1		_aLaVail, Matthew M. _eeditor.
700	1		_aBowes Rickman, Catherine. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461432081
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v801
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-1-4614-3209-8
912			_aZDB-2-SME
942			_2lcc _cEBOOKS
999			_c268768 _d268768