000 03741nam a22004815i 4500
001 978-1-4419-8056-4
003 DE-He213
005 20160615111650.0
007 cr nn 008mamaa
008 110628s2010 xxu| s |||| 0|eng d
020 _a9781441980564
_9978-1-4419-8056-4
024 7 _a10.1007/978-1-4419-8056-4
_2doi
049 _aAlfaisal Main Library
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
245 1 0 _aHistamine in Inflammation
_h[electronic resource] /
_cedited by Robin L. Thurmond.
264 1 _aBoston, MA :
_bSpringer US,
_c2010.
300 _aXVIII, 143 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v709
505 0 _aOne Hundred Years of Histamine Research -- Molecular Pharmacology of the Four Histamine Receptors -- Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient Mice -- Histamine in Allergic Rhinitis -- The Role of Histamine in Ocular Allergy -- The Role of Histamine in Asthma -- Antihistamines in the Treatment of Urticaria -- Histamine and Antihistamines in Atopic Dermatitis -- Histamine, Immune Cells and Autoimmunity -- Histamine in Neurotransmission and Brain Diseases -- Histamine in Normal and Malignant Cell Proliferation -- The Future Antihistamines: Histamine H3 and H4 Receptor Ligands.
520 _aThe year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aHuman Physiology.
655 7 _aElectronic books.
_2local
700 1 _aThurmond, Robin L.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441980557
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v709
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-1-4419-8056-4
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_cEBOOKS
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