000			03700nam a22005535i 4500
001			978-3-540-68119-9
003			DE-He213
005			20160615111950.0
007			cr nn 008mamaa
008			100301s2009 gw | s |||| 0|eng d
020			_a9783540681199 _9978-3-540-68119-9
024	7		_a10.1007/978-3-540-68119-9 _2doi
049			_aAlfaisal Main Library
050		4	_aRC109-216
072		7	_aMJCJ _2bicssc
072		7	_aMED022090 _2bisacsh
082	0	4	_a616.9 _223
245	1	4	_aThe Role of Biofilms in Device-Related Infections _h[electronic resource] / _cedited by Mark Shirtliff, Jeff G. Leid.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2009.
300			_aXII, 272 p. 31 illus., 17 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Series on Biofilms, _x1863-9607 ; _v3
505	0		_aMicrobial Ecology of Human Skin and Wounds -- Infections of Orthopaedic Implants and Devices -- Biofilms and Aseptic Loosening -- Biofilms and Ventilation -- Biofilm Formation on Natural Teeth and Dental Implants: What is the Difference? -- Complicated Urinary Tract Infections due to Catheters -- Biofilms in Hemodialysis -- Bacterial Endophthalmitis Following Cataract Surgery -- Use of Immunodiagnostics for the Early Detection of Biofilm Infections -- Immune Responses to Indwelling Medical Devices.
520			_aApproximately 60% of all hospital-associated infections, over one million cases per year, are due to biofilms that have formed on indwelling medical devices. Device-related biofilm infections increase hospital stays and add over one billion dollars/year to U.S. hospitalization costs. Since the use and the types of indwelling medical devices commonly used in modern healthcare are continuously expanding, especially with an aging population, the incidence of biofilm infections will also continue to rise. The central problem with microbial biofilm infections of foreign bodies is their propensity to resist clearance by the host immune system and all antimicrobial agents tested to date. In fact, compared to their free floating, planktonic counterparts, microbes within a biofilm are 50 – 500 times more resistant to antimicrobial agents. Therefore, achieving therapeutic and non-lethal dosing regimens within the human host is impossible. The end result is a conversion from an acute infection to one that is persistent, chronic, and recurrent, most often requiring device removal in order to eliminate the infection. This text will describe the major types of device-related infections, and will explain the host, pathogen, and the unique properties of their interactions in order to gain a better understanding of these recalcitrant infections.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aInfectious diseases.
650		0	_aMicrobiology.
650		0	_aBacteriology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aInfectious Diseases.
650	2	4	_aMicrobiology.
650	2	4	_aImmunology.
650	2	4	_aBacteriology.
655		7	_aElectronic books. _2local
700	1		_aShirtliff, Mark. _eeditor.
700	1		_aLeid, Jeff G. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540681137
830		0	_aSpringer Series on Biofilms, _x1863-9607 ; _v3
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-540-68119-9
912			_aZDB-2-SBL
942			_2lcc _cEBOOKS
999			_c297017 _d297017