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001 978-3-540-89615-9
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007 cr nn 008mamaa
008 100301s2009 gw | s |||| 0|eng d
020 _a9783540896159
_9978-3-540-89615-9
024 7 _a10.1007/978-3-540-89615-9
_2doi
049 _aAlfaisal Main Library
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
245 1 0 _aAdenosine Receptors in Health and Disease
_h[electronic resource] /
_cedited by Constance N. Wilson, S. Jamal Mustafa.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2009.
300 _aXIII, 652 p. 80 illus., 4 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v193
505 0 _ato Adenosine Receptors as Therapeutic Targets -- A1 Adenosine Receptor Antagonists, Agonists, and Allosteric Enhancers -- Recent Developments in Adenosine A2A Receptor Ligands -- Recent Developments in A2B Adenosine Receptor Ligands -- Medicinal Chemistry of the A3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering -- Adenosine Receptors and the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology -- Adenosine Receptors and Reperfusion Injury of the Heart -- Adenosine Receptors and Inflammation -- A1 Adenosine Receptor: Role in Diabetes and Obesity -- A3 Adenosine Receptor: Pharmacology and Role in Disease -- Adenosine Receptors and Asthma -- Adenosine Receptors, Cystic Fibrosis, and Airway Hydration -- Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis -- Adenosine Receptors and Cancer -- Adenosine Receptors and the Kidney -- Adenosine Receptors and the Central Nervous System -- Adenosine Receptors and Neurological Disease: Neuroprotection and Neurodegeneration -- Adenosine A2A Receptors and Parkinson’s Disease -- Adenosine Receptor Ligands and PET Imaging of the CNS.
520 _aSince their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aPharmacology.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aHuman Physiology.
650 2 4 _aCell Biology.
655 7 _aElectronic books.
_2local
700 1 _aWilson, Constance N.
_eeditor.
700 1 _aMustafa, S. Jamal.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540896142
830 0 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v193
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-540-89615-9
912 _aZDB-2-SBL
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_cEBOOKS
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