000			05735cam a2200589Ia 4500
001			ocn156878088
003			OCoLC
005			20180529113317.0
008			070720s2004 ne a ob 001 0 eng d
019			_a171114433 _a174039884 _a224901369 _a441778098 _a505089659 _a648303907 _a695549377 _a823826861 _a823895761 _a824088400 _a824134833
020			_a9780080490939 _q(electronic bk.)
020			_a008049093X _q(electronic bk.)
020			_a0121531600 _q(electronic bk.)
020			_a9780121531607 _q(electronic bk.)
020			_a1281005096
020			_a9781281005090
035			_a(OCoLC)156878088
040			_aDLC _beng _cDLC _dAU
049			_aAlfaisal Main Library
050		4	_aQH588.S83 _bS746 2004eb
060		4	_aW1 _bCU82G v.60 2004
060		4	_aQH 588.S83 _bS824 2004
245	0	0	_aStem cells in development and disease / _cedited by Gerald P. Schatten.
260			_aAmsterdam : _bBoston : _bElsevier Academic Press, _c©2004.
300			_a1 online resource (xii, 270 pages) : _billustrations (some color).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aCurrent topics in developmental biology ; _vv. 60
504			_aIncludes bibliographical references and index.
505	0		_aCover -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Therapeutic Cloning and Tissue Engineering -- I. Introduction -- II. Principles of Tissue Engineering -- III. Stem Cells -- IV. Therapeutic Cloning -- V. Applications of Tissue Engineering and Therapeutic Cloning -- References -- Chapter 2. a-Synuclein: Normal Function and Role in Neurodegenerative Diseases -- I. Introduction to the Synuclein Protein Family -- II. Synuclein in Synaptic Development and Maintenance -- III. Synuclein Protein Interactions -- IV. Synucleinopathies -- V. Structural Properties of a-Synuclein Protein -- VI. Implications of Oxidative and Nitrative Injury in Synucleinopathies -- VII. Effects of Oxidation and Nitration on a-Synuclein Fibril Formation -- VIII. Possible Role of Pesticides and Other Toxic Chemicals in PD -- IX. Transgenic and Nontransgenic Animal Models of Synucleinopathies -- X. Concluding Remarks -- Acknowledgments -- References -- Chapter 3. Structure and Function of Eukaryotic DNA Methyltransferases -- I. DNA Methylation: A Heritable Epigenetic Mark -- II. Eukaryotic DNA Methyltransferases -- III. Function of DNA Methylation -- IV. Concluding Remarks -- Acknowledgments -- References -- Chapter 4. Mechanical Signals as Regulators of Stem Cell Fate -- I. Introduction -- II. Mechanical Regulation of Limb Development -- III. Theoretical Models of Mechanical Stress in Development -- IV. In Vivo Experimentation -- V. In Vitro Experimentation -- VI. Conclusions -- Acknowledgment -- References -- Chapter 5. Origins of Mammalian Hematopoiesis: In Vivo Paradigms and In Vitro Models -- I. Introduction: The Hematopoietic System -- II. Hematopoiesis: De Muribus et Maribus -- III. Points of Divergence Between Murine and Human Blood Formation -- IV. Hematopoiesis from Embryonic Stem Cells -- V. What Remains To Be Learned? -- VI. Summary -- Acknowledgments -- References -- Chapter 6. Regulation of Gene Activity and Repression: A Consideration of Unifying Themes -- I. Introduction -- II. Regulation of Imprinted Gene Activity and Repression -- III. A Consideration of Recurrent Themes -- References -- Chapter 7. Molecular Basis for the Chloride Channel Activity of Cystic Fibrosis Transmembrane Conductance Regulator and the Consequences of Disease-Causing Mutations -- I. Introduction -- II. Role of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel Function in Tissue Physiology and Pathophysiology -- III. Cell Biology of CFTR and the Major CF Mutant (delta F508) -- IV. Quaternary Structure of CFTR -- V. The Permeation Pore of CFTR -- VI. Molecular Basis for Regulation by Phosphorylation -- VII. Molecular Basis for Regulation by Nucleotides -- VIII. Future Directions -- Acknowledgments -- References -- Index -- Contents of Previous Volumes -- Last Page.
520			_aThis volume of Current Topics in Developmental Biology showcases the research and therapeutic value of stem cells, and is proof of the increasing maturation of the fields of regenerative and molecular medicine. Reviews include:* Therapeutic cloning and tissue engineering to produce functional replacement tissues.* The role of the protein a-synuclein in a host of neurodegenerative diseases, which may be the first to benefit from stem cell therapy.* The curious array of functions in eukaryotic DNA methyltransferase, crucial for normal development and at the core of epigenetics regulation.* Influ.
588	0		_aPrint version record.
590			_aElsevier _bScienceDirect All Books
650		0	_aStem cells.
650		2	_aStem Cells _xphysiology.
650		2	_aEmbryonic Development.
650		2	_aEmbryonic and Fetal Development.
650		2	_aGenetic Phenomena _xphysiology.
650		2	_aTissue Engineering _xmethods.
650		6	_aCellules souches.
650		7	_aMEDICAL _xResearch. _2bisacsh
650		7	_aStem cells. _2fast _0(OCoLC)fst01132975
650	1	7	_aStamcellen. _2gtt
655		7	_aElectronic books. _2local
700	1		_aSchatten, Gerald, _eeditor.
710	2		_aScienceDirect eBooks.
776	0	8	_iPrint version: _tStem cells in development and disease. _dAmsterdam : Boston : Elsevier Academic Press, ©2004 _z0121531600 _z9780121531607 _w(DLC) 2004274666 _w(OCoLC)55765477
830		0	_aCurrent topics in developmental biology ; _vv. 60.
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/bookseries/00702153/60
942			_2lcc _cEBOOKS
264			_c©2004.
999			_c522029 _d522029