000 06555cam a2200577Ia 4500
001 ocn162129230
003 OCoLC
005 20180529113328.0
008 070802s1999 caua ob 001 0 eng d
010 _z 98089879
019 _a173260077
_a191035192
_a648307220
_a742284960
_a823829003
_a823898718
_a824090004
_a824136914
_a989397142
_a1035706131
020 _a9780125069656
020 _a0125069650
020 _a9781429498388
_q(electronic bk.)
020 _a1429498382
_q(electronic bk.)
020 _a0080529569
020 _a9780080529561
020 _a128103729X
020 _a9781281037299
035 _a(OCoLC)162129230
040 _aDLC
_beng
_cDLC
_dAU
049 _aAlfaisal Main Library
050 4 _aQR185.8.C6
_bM75 1999eb
060 0 0 _a2000 M-959
060 1 0 _aQW 680
_bM847ca 1999
100 1 _aMorgan, B. Paul.
245 1 0 _aComplement regulatory proteins /
_cB. Paul Morgan and Claire L. Harris.
260 _aSan Diego :
_bAcademic Press,
_c©1999.
300 _a1 online resource (xiv, 382 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
520 _aFrom small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the "nuts-and-bolts" of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators in vivo are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate! Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious. Key Features * Complement regulators--structure, functional roles and mode of action * Comprehensive reviews of each of the individual regulators * Roles of Complement regulators in vivo, in health and disease: * Consequences of deficiency * Roles in the reproductive system * Interactions with pathogens * Exploitation for therapy * Complement regulators in other species.
505 0 _aThe Complement System: A Brief Overview: -- Introduction. -- Activation of C. -- Physiological Roles of C. -- Involvement of C in Pathology. -- Why a Book on C Regulators? -- Regulation in the Complement System: -- Introduction. -- History. -- Control of Activation Pathways. -- Control in the Membrane Attack Pathway. -- Control of the Anaphylactic Peptides. -- Summary. -- Regulation in the Activation Pathways: -- Regulation of C1. -- Regulators Encoded in the RCA Gene Cluster. -- Other Regulators of the Activation Pathways. -- Regulation in the Terminal Pathway: -- Introduction. -- Fluid-Phase Regulators of the Terminal Pathway. -- Membrane Regulators of the Terminal Pathway. -- Recovery from C Membrane Attack. -- Concluding Remarks. -- Deficiencies of Complement Regulators: -- Introduction, Deficiency of C1 Inhibitor (C1inh). -- Deficiencies of Fluid-Phase C3 Convertase Regulators. -- Deficiencies of Fluid-Phase Membrane Attack Pathway Regulators. -- Deficiencies of Membrane Regulators of C. -- Concluding Remarks. -- Complement Regulation in the Reproductive System: -- Introduction. -- Role of C Inhibitors in the Protection of Sperm. -- Role of C Regulators in Protection of the Fetus. -- The Role of MCP in Fertilization. -- Concluding Remarks. -- Complement Regulators and Micro-Organisms: -- Introduction. -- Complement Regulators as Receptors for Microorgansims. -- Hijacking of Complement Regulators by Microorganisms. -- Molecular Mimicry. -- C5a-Peptidase/C5a-ASE. -- Conclusions. -- Complement Regulatory Proteins in Other Species: -- Introduction. -- Regulators of the Activation pathways. -- Regulators of the Terminal Pathway. -- Manipulation of Membrane C Regulators In Vivo. -- Complement Regulators in Therapy: -- Introduction. -- Therapy with Soluble C Regulators. -- Antibodies Against C Components as Therapeutics. -- Complement Regulators in Xenotransplantation. -- Anti-CRP Antibodies and Therapy. -- Concluding Remarks. -- Bibliography.
504 _aIncludes bibliographical references (pages 261-370) and index.
505 0 _aComplement system: a brief overview -- Regulation in the complement system -- Regulation in the activation pathways -- Regulation in the terminal pathway -- Deficiencies of complement regulators -- Complement regulation in the reproductive system -- Complement regulators and micro-organisms -- Complement regulatory proteins in other species -- Complement regulators in therapy.
588 0 _aPrint version record.
590 _aElsevier
_bScienceDirect All Books
650 0 _aComplement (Immunology)
650 7 _aMEDICAL
_xImmunology.
_2bisacsh
650 7 _aComplement (Immunology)
_2fast
_0(OCoLC)fst00871562
650 1 2 _aBlood Proteins.
650 1 2 _aComplement System Proteins.
650 2 2 _aMembrane Proteins.
655 7 _aElectronic books.
_2local
700 1 _aHarris, Claire L.
710 2 _aScienceDirect eBooks.
776 0 8 _iPrint version:
_aMorgan, B. Paul.
_tComplement regulatory proteins.
_dSan Diego : Academic Press, ©1999
_z0125069650
_z9780125069656
_w(DLC) 98089879
_w(OCoLC)41012048
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/book/9780125069656
942 _2lcc
_cEBOOKS
264 _c©1999.
999 _c522357
_d522357