000 06461cam a2200553Ma 4500
001 ocn464869697
003 OCoLC
005 20180529114435.0
008 990623s1999 ctua ob 001 0 eng
019 _a297238411
_a808731360
_a823836719
_a823905063
_a824094775
_a824147189
020 _a9780080877136
_q(electronic bk.)
020 _a0080877133
_q(electronic bk.)
020 _a0762304952
_q(electronic bk.)
020 _a9780762304950
_q(electronic bk.)
020 _a1281716782
020 _a9781281716781
035 _a(OCoLC)464869697
040 _aDLC
_beng
_cDLC
_dAU
049 _aAlfaisal Main Library
050 4 _aQH623
_b.A33 1999
245 0 4 _aThe adhesive interaction of cells /
_cseries editor, E. Edward Bittar ; guest editors, David R. Garrod, Alison J. North, Martyn A.J. Chidgey.
260 _aStamford, Conn. :
_bJAI Press,
_c1999.
300 _a1 online resource (xii, 415 pages) :
_billustrations.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aAdvances in molecular and cell biology ;
_vv. 28
504 _aIncludes bibliographical references and index.
520 _aThe aim of "The Adhesive Interaction of Cells" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than "glue". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth. The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic.
505 0 _aFront Cover; Advances in Molecular and Cell Biology: The Adhesive Interaction of Cells; Copyright Page; CONTENTS; LIST OF CONTRIBUTORS; PREFACE; PART I: ADHESION MOLECULES AND THEIR LIGANDS; CHAPTER 1. THE MOLECULAR ANATOMY OF INTEGRINS; CHAPTER 2. THE CADHERIN SUPERFAMILY; CHAPTER 3. THE SELECTINS AND THEIR LIGANDS: ADHESION MOLECULES OF THE VASCULATURE; CHAPTER 4. THE IMMUNOGLOBULIN SUPERFAMILY; PART II: ORGANIZATION OF ADHESION COMPLEXES; CHAPTER 1. FOCAL ADHESIONS AND ADHERENS JUNCTIONS: THEIR ROLE IN TUMORIGENESIS; CHAPTER 2. DESMOSOMAL ADHESION.
505 8 _aCHAPTER 3. THE MOLECULAR BASIS FOR THE STRUCTURE, FUNCTION, AND REGULATION OF TIGHT JUNCTIONSPART III: SIGNALING BY ADHESION MOLECULES; CHAPTER 1. ACTIVATION OF INTEGRIN SIGNALING PATHWAYS BY CELL INTERACTIONS WITH EXTRACELLULAR MATRIX; CHAPTER 2. SIGNALING AND PLATELET ADHESION; CHAPTER 3. SIGNALING BY CELL ADHESION MOLECULES IN THE NERVOUS SYSTEM; PART IV: ADHESIVE PROCESSES; CHAPTER 1. VASCULAR ENDOTHELIAL CELL ADHESION MOLECULES AND THE CONTROL OF LEUKOCYTE TRAFFIC IN CUTANEOUS INFLAMMATION.
505 8 _aCHAPTER 2. THE ROLE OF ADHESION IN METASTASIS: POTENTIAL MECHANISMS AND MODULATION OF INTEGRIN ACTIVITYCHAPTER 3. INTEGRIN ADHESION IN CELL MIGRATION; CHAPTER 4. ADHESION RECEPTORS: CRITICAL EFFECTORS OF TROPHOBLAST DIFFERENTIAT ION DURING IMPLANTATI0N AND PLACENTATlON; INDEX.
590 _aElsevier
_bScienceDirect All Books
650 0 _aCell adhesion.
650 0 _aCell adhesion molecules.
650 7 _aSCIENCE
_xLife Sciences
_xMolecular Biology.
_2bisacsh
650 7 _aCell adhesion.
_2fast
_0(OCoLC)fst00850164
650 7 _aCell adhesion molecules.
_2fast
_0(OCoLC)fst00850166
655 7 _aElectronic books.
_2local
700 1 _aBittar, E. E.
700 1 _aGarrod, D. R.
_q(David Ronald),
_d1944-
700 1 _aNorth, Alison J.
700 1 _aChidgey, Martyn A. J.
710 2 _aScienceDirect eBooks.
776 0 8 _iPrint version:
_tAdhesive interaction of cells.
_dStamford, Conn. : JAI Press, 1999
_z0762304952
_z9780762304950
_w(OCoLC)41598018
830 0 _aAdvances in molecular and cell biology ;
_vv. 28.
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/bookseries/15692558/28
942 _2lcc
_cEBOOKS
264 _c1999.
999 _c530078
_d530078