000			04810cam a2200553Ii 4500
001			ocn950518680
003			OCoLC
005			20180529115737.0
008			160525s2016 enk o 001 0 eng d
019			_a951222629
020			_a9780128018033 _qelectronic bk.
020			_a0128018038 _qelectronic bk.
020			_z9780128016633
020			_z0128016639
035			_a(OCoLC)950518680
040			_aDLC _beng _cDLC _dAU
049			_aAlfaisal Main Library
050		4	_aRA1224.3
245	0	0	_aThresholds of genotoxic carcinogens : _bfrom mechanisms to regulation / _cedited by Takehiko Nohmi, Shoji Fukushima.
264		1	_aLondon, UK : _bAcademic Press is an imprint of Elsevier, _c2016.
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aIncludes index.
588	0		_aOnline resource; title from PDF title page (ScienceDirect, viewed June 6, 2016).
505	0		_aTitle page; Table of Contents; Copyright; List of Contributors; Preface; Chapter 1. Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose-Response for Key Events in Rat Hepatocarcinogenesis; Abstract; Introduction; Qualitative and Quantitative Analyses on Low-Dose Carcinogenicity of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Rat Liver; Qualitative and Quantitative Analyses on Low-Dose Hepatocarcinogenicity of 2-Amino-3-methylimidazo[4,5-f]quinoline in the Rat Liver
505	8		_aQualitative and Quantitative Analysis on Low-Dose Hepatocarcinogenicity of N-nitrosodiethylamine in the Rat LiverDiscussion; References; Chapter 2. Thresholds for Hepatocarcinogenicity of DNA-Reactive Compounds; Abstract; Introduction; Dose-Effect Studies of Initiation of Liver Carcinogenesis; Conclusions; Relevance to Humans; References; Chapter 3. Interaction of Low-Dose Radiation and Chemicals in Cancer Risk; Abstract; Epidemiological Analysis of Cancer Risk; Interaction of Radiation and Other Carcinogens; Data From Animal Experiments; Conclusion; Acknowledgments; References
505	8		_aChapter 4. Possible Mechanisms Underlying Genotoxic Thresholds: DNA Repair and Translesion DNA SynthesisAbstract; Introduction; Challenges in Identification of Genotoxicity of Chemicals; Possible Mechanisms Underlying Genotoxic Thresholds; Significance of DNA Repair Mechanisms in the Suppression of Mutagenesis and Tumorigenesis in Mammals; TLS as a Critical Factor for Mutagenesis; Future Perspectives; Acknowledgments; References; Chapter 5. DNA Repair and Its Influence on Points of Departure for Alkylating Agent Genotoxicity; Abstract; Introduction
505	8		_aThe Paradigm Shift in Response to Low Doses of Alkylating AgentsAlkylating Agent Mechanism of Action; DNA Repair of Alkyl Adducts: Potential Influences on PoDs; Mechanistic Evidence Supporting a PoD for EMS; Mechanistic Evidence Supporting a PoD for ENU; Mechanistic Evidence Supporting a PoD for MMS; Mechanistic Evidence Supporting a PoD for MNU; Concluding Remarks; References; Chapter 6. The Role of Endogenous Versus Exogenous DNA Damage in Risk Assessment; Abstract; Introduction; Aldehydes; Alkylating Agents; Oxidative Stress; Ionizing Radiation
505	8		_aQuantifying Complex Dose-Response Relationships to Support Risk AssessmentsConclusion; References; Chapter 7. Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals; Abstract; Introduction; Genotoxic and Nongenotoxic Carcinogens; Thresholds of Chemical Genotoxicity; Risk Management for Genotoxic Carcinogens; Risk Assessment and Control of Genotoxic Impurities in Pharmaceuticals; Conclusion; References; Chapter 8. Practical Thresholds in the Derivation of Occupational Exposure Limits (OELs) for Carcinogens; Abstract; Introduction
590			_aElsevier _bScienceDirect All Books
650		0	_aGenetic toxicology.
650		0	_aCarcinogenesis.
650		7	_aHEALTH & FITNESS / Diseases / General _2bisacsh
650		7	_aMEDICAL / Clinical Medicine _2bisacsh
650		7	_aMEDICAL / Diseases _2bisacsh
650		7	_aMEDICAL / Evidence-Based Medicine _2bisacsh
650		7	_aMEDICAL / Internal Medicine _2bisacsh
650		7	_aCarcinogenesis. _2fast _0(OCoLC)fst00846974
650		7	_aGenetic toxicology. _2fast _0(OCoLC)fst00940097
655		7	_aElectronic books. _2local
700	1		_aNohmi, Takehiko, _eeditor.
700	1		_aFukushima, Shoji, _eeditor.
710	2		_aScienceDirect eBooks.
776	0	8	_iPrint version: _aNohmi, Takehiko _tThresholds of Genotoxic Carcinogens : From Mechanisms to Regulation _d: Elsevier Science,c2016 _z9780128016633
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/book/9780128016633
942			_2lcc _cEBOOKS
260			_c2016.
999			_c540876 _d540876