000			04835cam a2200553Ia 4500
001			on1008876289
003			OCoLC
005			20180529120013.0
008			171101s2017 ne ob 001 0 eng d
019			_a1008989655 _a1031876110
020			_a9780128043240 _q(electronic bk.)
020			_a0128043245 _q(electronic bk.)
020			_z9780128042793
020			_z0128042796
035			_a(OCoLC)1008876289
040			_aDLC _beng _cDLC _dAU
049			_aAlfaisal Main Library
050		4	_aQP375
245	0	0	_aCerebrospinal fluid in neurologic disorders / _cvolume editors, Florian Deisenhammer, Charlotte E. Teunissen, and Hayrettin Tumani.
260			_aAmsterdam : _bElsevier, _c2017.
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aHandbook of clinical neurology ; _vvolume 146
588	0		_aOnline resource; title from PDF title page (EBSCO, viewed November 1, 2017)
504			_aIncludes bibliographical references and index.
505	0		_a""Front Cover""; ""Cerebrospinal Fluid in Neurologic Disorders""; ""Copyright""; ""Available titles""; ""Foreword""; ""Preface""; ""Contributors""; ""Contents""; ""Section I: General aspects""; ""Chapter 1: The use of cerebrospinal fluid in biomarker studies""; ""Introduction""; ""Definition of biomarkers and type of biomarkers""; ""Physiology of CSF""; ""Biomarker subtypes""; ""Proteins""; ""Metabolites""; ""Cell-free DNA""; ""Messenger RNA/micro RNA""; ""Exosomes""; ""Sample collection and biobanking: preanalytic variation""; ""Patient-related factors""; ""Age and sex""
505	8		_a""Genetic background""""Circadian rhythm""; ""Coffee, chocolate, smoking, and alcohol consumption""; ""Preanalytic procedures""; ""Lumbar puncture""; ""Risk factors and recommendations in performing an LP""; ""Type of tube""; ""Evaporation""; ""Centrifugation speed and temperature""; ""Quality assessment of collection procedures""; ""Analytic aspects in CSF biomarker studies: assay development and validation""; ""Technical analysis: optimizing immunoassay validation and development of novel biomarkers""; ""Quality assessment of analytic procedures""; ""Matrix reference material""
505	8		_a""Clinical study design in CSF biomarker studies""""Discussion: how to increase the number of novel biomarkers?""; ""Concluding remarks""; ""References""; ""Chapter 2: The cerebrospinal fluid and barriers -- anatomic and physiologic considerations""; ""Introduction""; ""Physiology of CSF: what is CSF good for, where does it come from, how is it circulating, where does it go?""; ""Biologic function""; ""Sites of production""; ""Circulation""; ""Absorption""; ""Transfer mechanisms""; ""Barriers of the CNS compartment: what are the differences between BBB and BCB?""; ""The blood-brain barrier""
505	8		_a""The blood-CSF barrier""""Anatomy of CSF spaces: which brain areas are reflected by CSF analysis?""; ""CSF constituents: which factors influence their concentration and what is their implication for CSF analysis?""; ""Circadian changes""; ""Site of sampling (lumbar vs. ventricular CSF)""; ""Volume of CSF sampled""; ""Physical activity and head movement""; ""Clearance via specific transporters""; ""Surgical intervention""; ""Concluding remarks""; ""References""; ""Chapter 3: More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue""
505	8		_a""The concept of volume transmission""""The functional influence of CSF on brain cells""; ""Adult neurogenesis""; ""CSF-contacting neurons""; ""The functional contribution of CSF in pathologic CNS conditions""; ""Traumatic brain injury (TBI)""; ""Anti-NMDAR encephalopathy""; ""Brain aging and dementia""; ""Summary""; ""Abbreviations""; ""References""; ""Chapter 4: Dosing, collection, and quality control issues in cerebrospinal fluid research using animal models""; ""Introduction""; ""CSF and brain interstitial fluid""
590			_aElsevier _bScienceDirect All Books
650		0	_aCerebrospinal fluid.
650		7	_aMEDICAL / Physiology. _2bisacsh
650		7	_aSCIENCE / Life Sciences / Human Anatomy & Physiology. _2bisacsh
650		7	_aCerebrospinal fluid. _2fast _0(OCoLC)fst00851350
650	1	2	_aCerebrospinal Fluid.
650	2	2	_aNervous System Diseases.
655		7	_aElectronic books. _2local
700	1		_aDeisenhammer, Florian.
700	1		_aTeunissen, Charlotte E.
700	1		_aTumani, Hayrettin.
710	2		_aScienceDirect eBooks.
776	0	8	_cOriginal _z9780128042793 _z0128042796 _w(OCoLC)986237295
830		0	_aHandbook of clinical neurology ; _vvolume 146.
856	4	0	_uhttp://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/handbooks/00729752/146
942			_2lcc _cEBOOKS
264			_c2017.
999			_c542703 _d542703