000 06947cam a2200565Ii 4500
001 on1020172350
003 OCoLC
005 20180529120022.0
008 180123s2018 mau ob 000 0 eng d
019 _a1020422929
_a1020695150
020 _a9780128141175
_q(electronic bk.)
020 _a0128141174
_q(electronic bk.)
020 _a9780128141168
020 _a0128141166
035 _a(OCoLC)1020172350
040 _aDLC
_beng
_cDLC
_dAU
049 _aAlfaisal Main Library
050 4 _aQP572.T5
_bT497 2018eb
245 0 0 _aThyroid Hormone /
_cseries editor, Gerald Litwack.
250 _aFirst edition.
264 1 _aCambaridge, MA, United States :
_bAcademic Press,
_c2018.
300 _a1 online resource (xx, 544 pages :
_billustrations).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aVitamins and hormones ;
_vvolume 106
546 _aText in English.
504 _aIncludes bibliographical references.
505 0 _aThyroid Hormone Receptor Antagonists: From Environmental Pollution to Novel Small Molecules Louise S. Mackenzie 8. Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation Mikaela M. Sifuentes and James D. Lechleiter 9. The NF--[kappa]B Family of Transcription Factors and Its Role in Thyroid Physiology Carla Reale, Tiziana Zotti, Ivan Scudiero, Pasquale Vito and Romania Stilo 10. Thyroid Hormone Regulation of Adult Neurogenesis Sashaina E. Fanibunda, Lynette A. Desouza, Richa Kapoor, Rama A. Vaidya and Vidita A. Vaidya 11. Thyroid Hormone and the White Matter of the Central Nervous System: From Development to Repair Laura Calzà, Vito A. Baldassarro, Mercedes Fernandez, Alessandro Giuliani, Luca Lorenzini and Luciana Giardino 12.
505 0 _a1. Local Regulation of Thyroid Hormone Signaling Alexander G. Little 2. Thyroid Hormone Transport and Transporters Doreen Braun and Ulrich Schweizer 3. Nuclear Import and Export of the Thyroid Hormone Receptor Jibo Zhang, Vincent R. Roggero and Lizabeth A. Allison 4. Molecular Basis of Nongenomic Actions of Thyroid Hormone Paul J. Davis, Jack L. Leonard, Hung-Yun Lin, Matthew Leinung and Shaker A. Mousa 5. The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin [Beta] Subunit Gene Shigekazu Sasaki, Akio Matsushita, Go Kuroda, Hiroko M. Nakamura, Yutaka Oki and Takafumi Suda 6. Thyroid Autoimmunity: An Interplay of Factors Stephen J. Merrill and Sarah B. Minucci 7.
505 0 _aFront Cover; Thyroid Hormone; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Local Regulation of Thyroid Hormone Signaling; 1. Introduction; 2. Bioavailability; 2.1. TH Transporters; 2.2. Deiodinases; 2.3. Intracellular Reservoir Proteins; 3. Bioactivity; 3.1. Thyroid Receptors; 3.2. Integrin αvÃ#x9F;3; 3.3. Thyroid Response Elements; 4. Conclusions; References; Further Reading; Chapter Two: Thyroid Hormone Transport and Transporters; 1. Introduction; 2. Thyroid hormone Transport; 3. Monocarboxylate Transporter 8; 3.1. The Syndrome of Inherited MCT8 Deficiency
505 8 _a3.2. Mutations in MCT8 Impair Thyroid Hormone Transport3.3. Concepts for Treatment of MCT8 Deficiency; 3.3.1. Raising Low T4; 3.3.2. Lowering Elevated T3; 3.3.3. Replacing Thyroid Hormone With an MCT8-Independent Agonist; 4. Mouse Models of Allan-Herndon-Dudley Syndrome; 5. Thyroid Hormone Transport and Physiology; 6. Further Clinical Implications for Thyroid Hormone Transporters; 6.1. Polymorphisms in Thyroid Hormone Transporters May Affect Thyroid Hormone Levels; 6.2. Inhibition of Thyroid Hormone Transport by Drugs; 6.3. Intestinal Uptake of T4 and Thyroid Hormone Transport
505 8 _a7. Conclusions and Future DirectionsAcknowledgments; References; Chapter Three: Nuclear Import and Export of the Thyroid Hormone Receptor; 1. Introduction; 2. Thyroid Hormone Receptor Nucleocytoplasmic Shuttling; 2.1. Translocation Through the Nuclear Pore Complexes; 2.2. Analysis of Nucleocytoplasmic Shuttling in Live Cells; 3. Nuclear Import Pathways of TR; 3.1. NLSs in TRα1; 3.1.1. Hinge Domain NLS; 3.1.2. A/B Domain NLS; 3.2. Importins That Mediate TRα1 Nuclear Import; 3.2.1. Importin α1/Ã#x9F;1 Heterodimer; 3.2.2. Importin 7; 4. Nuclear Export Pathways of TRα1; 4.1. NESs in TRα1
505 8 _a4.1.1. NES-H124.1.2. NES-H3 and NES-H6; 4.2. Exportins That Mediate TRα1 Nuclear Export; 4.2.1. CRM1; 4.2.2. Exportins 4, 5, and 7; 5. Mislocalization of TR and Pathogenesis; 5.1. TR Mislocalization and Cancer; 5.2. TR Mislocalization and RTH Syndrome; 6. Conclusions and Future Directions; Acknowledgments; References; Chapter Four: Molecular Basis of Nongenomic Actions of Thyroid Hormone; 1. Introduction; 2. Regulation of the State of the Cytoskeleton by Thyroid Hormone; 3. Regulation of Mitochondrial Respiration by Thyroid Hormone
505 8 _a4. Nongenomic Actions of Truncated and Intact TRs in Cytoplasm on Bone Cells, Neurons, and Tumor Suppression5. Cytoplasmic Proteins in Addition to TRs That Mediate Nongenomic Actions of Thyroid Hormone; 6. Nongenomic Actions of Thyroid Hormone Initiated at Plasma Membrane; 7. Thyroid Hormone Receptor on Plasma Membrane Integrin αvÃ#x9F;3; 8. Thyroid Hormone αvÃ#x9F;3 Receptor and Angiogenesis; 9. Thyroid Hormone αvÃ#x9F;3 Receptor and Tumor Cell Proliferation; 10. Thyroid Hormone αvÃ#x9F;3 Receptor and Regulation of Gene Expression; 11. Thyroid Hormone αvÃ#x9F;3 Receptor and Cell Physiology; 12. Discussion
520 _aThyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics.
590 _aElsevier
_bScienceDirect All Books
650 0 _aThyroid hormones.
650 7 _aMEDICAL / Physiology.
_2bisacsh
650 7 _aSCIENCE / Life Sciences / Human Anatomy & Physiology.
_2bisacsh
650 7 _aThyroid hormones.
_2fast
_0(OCoLC)fst01150595
650 2 _aThyroid Hormones.
655 7 _aElectronic books.
_2local
700 1 _aLitwack, Gerald,
_eeditor.
710 2 _aScienceDirect eBooks.
776 0 8 _iPrint version:
_z0128141166
_z9780128141168
_w(OCoLC)994360317
830 0 _aVitamins and hormones ;
_vv. 106.
856 4 0 _uhttp://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/bookseries/00836729/106
942 _2lcc
_cEBOOKS
260 _c2018.
999 _c542998
_d542998