000			05346cam a2200601Mu 4500
999			_c5573 _d5573
001			10986057
003			OSt
005			20171207085556.0
006			m o d
007			cr cnu---unuuu
008			140913s2014 xx o 000 0 eng d
020			_a9780124167216 (Hardcover)
020			_z9780124167285 (eBook)
024			_ceng
035			_a(NNC)10986057
035			_a(OCoLC)ocn890530087
040			_aEBLCP _beng _cEBLCP _dAU
049			_aAlfaisal Main Library
050		4	_aRD675 _b.B384 2014
082	0	4	_a616.99471
100	1		_aHeymann, Dominique.
245	1	0	_aBone Cancer _h : _bPrimary Bone Cancers and Bone Metastases.
250			_a2nd ed.
260			_aBurlington : _bElsevier Science, _c©2014.
264			_aBurlington : _bElsevier Science, _c©2014.
300			_a1 online resource (730 p.)
500			_aDescription based upon print version of record.
505	0		_aCover; Title page; Copyright page; Table of Contents; List of Contributors; Foreword; Preface; Part I -- Basic aspects of bone cancers; Section 1 -- Epidemiology of bone cancer; Chapter 1 -- Epidemiology of primary bone tumors and economical aspects of bone metastases; Introduction; Incidence of primary bone tumors; Age; Gender; Site distribution; Incidence of bone tumors as a secondary event; Racial differences in incidence of primary bone tumors; Incidence of bone metastases; Pathology of bone metastases; Cost of illness; Economical burden of bone metastasis; Conclusions; References
505	8		_6880-01 _aBone-derived factors stimulating tumor cellsOther ways osteoclasts contribute to the bone-tumor niche; References; Chapter 6 -- Involvement of osteocytes in cancer bone niche; Introduction; Osteocytes: A multifunctional bone cell; Short overview of RANK/RANKL/osteoprotegerin and canonical Wnt signaling pathways; Central role of osteocytes in bone remodeling through RANKL and sclerostin regulation; Deregulation of RANK/RANKL and Wnt pathways in malignancy; Is there a direct link between malignant cells and osteocytes?; Conclusions and perspectives; References
505	8		_aChapter 7 -- Role of mesenchymal stem cells in bone cancer
505	8		_aNiche and microenvironmentOsteoblastic and endothelial niches; Bone marrow stromal cells and the niche; The heterotopic transplantation system; An adaptive niche; Modeling the niche and probing its significance in disease; The niche in early metastatic growth; Acknowledgments; References; Chapter 4 -- Deregulation of osteoblast differentiation in primary bone cancers; Introduction; Normal osteoblastogenesis: general process and major regulatory mechanisms; Deregulated genes in bone tumors; Tumor suppressor genes; Oncogenes; Transcription factors; Deregulated signaling pathways in bone tumors
505	8		_aSection 2 -- Bone microenvironmentand bone cancerChapter 2 -- Tumor-bone interactions: there is no place like bone; Introduction; Making its way to bone; Disseminated tumor cells and dormancy in bone; Induction of osteolysis by cancer cells in bone; Induction of bone formation by cancer cells in bone; Suppression of bone formation; The bone microenvironment support cancer cell growth; Conclusion; References; Chapter 3 -- Stem cell niches in the bone-bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer; Introduction; The concept of a niche
520			_aBone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been wri.
650		0	_aBones _xCancer _xTreatment.
650		0	_aBones _xCancer.
650		4	_aBone neoplasms.
650		4	_aBones -- Cancer -- Treatment.
650		4	_aBones -- Cancer.
650		7	_aHEALTH & FITNESS / Diseases / General _2bisacsh
650		7	_aMEDICAL / Clinical Medicine _2bisacsh
650		7	_aMEDICAL / Diseases _2bisacsh
650		7	_aMEDICAL / Evidence-Based Medicine _2bisacsh
650		7	_aMEDICAL / Internal Medicine _2bisacsh
655		7	_aPrint books. _2local
880	8		_6505-01/(S _aBone morphogenetic protein BMP and transforming growth factor-(Sb (B(TGF-(Sb(B) signalingReceptor tyrosine kinase signaling; Intracellular signaling pathways; Wnt signaling; Deregulation of local regulatory mechanisms in bone tumors; Cell-cell interactions; Cell-matrix interactions; Microenvironmental factors; Conclusions and perspectives; Acknowledgments; References; Chapter 5 -- Contribution of osteoclasts to the bone-tumor niche; Introduction; Osteoclastogenesis; Bone resorption; The vicious cycle of tumor-bone metastases; Tumor-derived factors stimulating osteoclasts
942			_2lcc _cBOOKS