000			03494cam a22005295i 4500
999			_c601931 _d601931
001			21664061
003			US-DLC
005			20220210113651.0
006			m |o d |
007			cr |||||||||||
008			131119s2014 xxk|||| o |||| 0|eng
010			_a 2019740612
020			_a9781447172567
024	7		_a10.1007/978-1-4471-5553-9 _2doi
035			_a(DE-He213)978-1-4471-5553-9
040			_aDLC _beng _epn _erda _cDLC
049			_aAlfaisal Main Library
050			_aR117 _b.B873 2016
100	1		_aBurcham, Philip C. _eauthor.
245	1	3	_aAn Introduction to Toxicology / _cby Philip C. Burcham.
250			_a1st ed. 2014.
260			_c©2016
264		1	_aLondon : _bSpringer London : _bImprint: Springer, _c©2016
300			_a(XVI, 327 pages 93 illustrations, 1 illustrations in color.)
336			_atext _btxt _2rdacontent
505	0		_aThe Emergence of Modern Toxicology -- Core Concepts in Toxicology -- Toxicokinetics - The Fate of Chemicals within the Body -- Toxicodynamics - How Chemicals Induce Toxicity -- Fightback - Adaptive Responses to Toxicant Exposure -- Target Organ Toxicity: Liver and Kidney -- Chemical Toxicity to the Unborn.- Chemicals and Cancer.- Everyday Toxicology I - Alcohol.- Everyday Toxicology II - Tobacco. .
520			_a This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960's as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that "unpack" the concepts being discussed in the text. .
650		0	_aPharmacology.
650		0	_aMolecular biology.
650		0	_aMedicine.
650	1	4	_aPharmacology/Toxicology.
650	2	4	_aMolecular Medicine.
650	2	4	_aBiomedicine, general.
655		0	_2local _94 _aPrint books.
776	0	8	_iPrinted edition: _z9781447155546
776	0	8	_iPrinted edition: _z9781447155522
776	0	8	_iPrinted edition: _z9781447172567
942			_2lcc _cBOOKS