Description based upon print version of record.

Cover; Title page; Copyright page; Table of Contents; List of Contributors; Foreword; Preface; Part I -- Basic aspects of bone cancers; Section 1 -- Epidemiology of bone cancer; Chapter 1 -- Epidemiology of primary bone tumors and economical aspects of bone metastases; Introduction; Incidence of primary bone tumors; Age; Gender; Site distribution; Incidence of bone tumors as a secondary event; Racial differences in incidence of primary bone tumors; Incidence of bone metastases; Pathology of bone metastases; Cost of illness; Economical burden of bone metastasis; Conclusions; References

880-01 Bone-derived factors stimulating tumor cellsOther ways osteoclasts contribute to the bone-tumor niche; References; Chapter 6 -- Involvement of osteocytes in cancer bone niche; Introduction; Osteocytes: A multifunctional bone cell; Short overview of RANK/RANKL/osteoprotegerin and canonical Wnt signaling pathways; Central role of osteocytes in bone remodeling through RANKL and sclerostin regulation; Deregulation of RANK/RANKL and Wnt pathways in malignancy; Is there a direct link between malignant cells and osteocytes?; Conclusions and perspectives; References

Chapter 7 -- Role of mesenchymal stem cells in bone cancer

Niche and microenvironmentOsteoblastic and endothelial niches; Bone marrow stromal cells and the niche; The heterotopic transplantation system; An adaptive niche; Modeling the niche and probing its significance in disease; The niche in early metastatic growth; Acknowledgments; References; Chapter 4 -- Deregulation of osteoblast differentiation in primary bone cancers; Introduction; Normal osteoblastogenesis: general process and major regulatory mechanisms; Deregulated genes in bone tumors; Tumor suppressor genes; Oncogenes; Transcription factors; Deregulated signaling pathways in bone tumors

Section 2 -- Bone microenvironmentand bone cancerChapter 2 -- Tumor-bone interactions: there is no place like bone; Introduction; Making its way to bone; Disseminated tumor cells and dormancy in bone; Induction of osteolysis by cancer cells in bone; Induction of bone formation by cancer cells in bone; Suppression of bone formation; The bone microenvironment support cancer cell growth; Conclusion; References; Chapter 3 -- Stem cell niches in the bone-bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer; Introduction; The concept of a niche

Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been wri.