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Thresholds of genotoxic carcinogens : from mechanisms to regulation / edited by Takehiko Nohmi, Shoji Fukushima.

Contributor(s): Publisher: London, UK : Academic Press is an imprint of Elsevier, 2016Description: 1 online resourceContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9780128018033
  • 0128018038
Subject(s): Genre/Form: Additional physical formats: Print version:: Thresholds of Genotoxic Carcinogens : From Mechanisms to RegulationLOC classification:
  • RA1224.3
Online resources:
Contents:
Title page; Table of Contents; Copyright; List of Contributors; Preface; Chapter 1. Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose-Response for Key Events in Rat Hepatocarcinogenesis; Abstract; Introduction; Qualitative and Quantitative Analyses on Low-Dose Carcinogenicity of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Rat Liver; Qualitative and Quantitative Analyses on Low-Dose Hepatocarcinogenicity of 2-Amino-3-methylimidazo[4,5-f]quinoline in the Rat Liver
Qualitative and Quantitative Analysis on Low-Dose Hepatocarcinogenicity of N-nitrosodiethylamine in the Rat LiverDiscussion; References; Chapter 2. Thresholds for Hepatocarcinogenicity of DNA-Reactive Compounds; Abstract; Introduction; Dose-Effect Studies of Initiation of Liver Carcinogenesis; Conclusions; Relevance to Humans; References; Chapter 3. Interaction of Low-Dose Radiation and Chemicals in Cancer Risk; Abstract; Epidemiological Analysis of Cancer Risk; Interaction of Radiation and Other Carcinogens; Data From Animal Experiments; Conclusion; Acknowledgments; References
Chapter 4. Possible Mechanisms Underlying Genotoxic Thresholds: DNA Repair and Translesion DNA SynthesisAbstract; Introduction; Challenges in Identification of Genotoxicity of Chemicals; Possible Mechanisms Underlying Genotoxic Thresholds; Significance of DNA Repair Mechanisms in the Suppression of Mutagenesis and Tumorigenesis in Mammals; TLS as a Critical Factor for Mutagenesis; Future Perspectives; Acknowledgments; References; Chapter 5. DNA Repair and Its Influence on Points of Departure for Alkylating Agent Genotoxicity; Abstract; Introduction
The Paradigm Shift in Response to Low Doses of Alkylating AgentsAlkylating Agent Mechanism of Action; DNA Repair of Alkyl Adducts: Potential Influences on PoDs; Mechanistic Evidence Supporting a PoD for EMS; Mechanistic Evidence Supporting a PoD for ENU; Mechanistic Evidence Supporting a PoD for MMS; Mechanistic Evidence Supporting a PoD for MNU; Concluding Remarks; References; Chapter 6. The Role of Endogenous Versus Exogenous DNA Damage in Risk Assessment; Abstract; Introduction; Aldehydes; Alkylating Agents; Oxidative Stress; Ionizing Radiation
Quantifying Complex Dose-Response Relationships to Support Risk AssessmentsConclusion; References; Chapter 7. Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals; Abstract; Introduction; Genotoxic and Nongenotoxic Carcinogens; Thresholds of Chemical Genotoxicity; Risk Management for Genotoxic Carcinogens; Risk Assessment and Control of Genotoxic Impurities in Pharmaceuticals; Conclusion; References; Chapter 8. Practical Thresholds in the Derivation of Occupational Exposure Limits (OELs) for Carcinogens; Abstract; Introduction
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Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed June 6, 2016).

Title page; Table of Contents; Copyright; List of Contributors; Preface; Chapter 1. Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose-Response for Key Events in Rat Hepatocarcinogenesis; Abstract; Introduction; Qualitative and Quantitative Analyses on Low-Dose Carcinogenicity of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Rat Liver; Qualitative and Quantitative Analyses on Low-Dose Hepatocarcinogenicity of 2-Amino-3-methylimidazo[4,5-f]quinoline in the Rat Liver

Qualitative and Quantitative Analysis on Low-Dose Hepatocarcinogenicity of N-nitrosodiethylamine in the Rat LiverDiscussion; References; Chapter 2. Thresholds for Hepatocarcinogenicity of DNA-Reactive Compounds; Abstract; Introduction; Dose-Effect Studies of Initiation of Liver Carcinogenesis; Conclusions; Relevance to Humans; References; Chapter 3. Interaction of Low-Dose Radiation and Chemicals in Cancer Risk; Abstract; Epidemiological Analysis of Cancer Risk; Interaction of Radiation and Other Carcinogens; Data From Animal Experiments; Conclusion; Acknowledgments; References

Chapter 4. Possible Mechanisms Underlying Genotoxic Thresholds: DNA Repair and Translesion DNA SynthesisAbstract; Introduction; Challenges in Identification of Genotoxicity of Chemicals; Possible Mechanisms Underlying Genotoxic Thresholds; Significance of DNA Repair Mechanisms in the Suppression of Mutagenesis and Tumorigenesis in Mammals; TLS as a Critical Factor for Mutagenesis; Future Perspectives; Acknowledgments; References; Chapter 5. DNA Repair and Its Influence on Points of Departure for Alkylating Agent Genotoxicity; Abstract; Introduction

The Paradigm Shift in Response to Low Doses of Alkylating AgentsAlkylating Agent Mechanism of Action; DNA Repair of Alkyl Adducts: Potential Influences on PoDs; Mechanistic Evidence Supporting a PoD for EMS; Mechanistic Evidence Supporting a PoD for ENU; Mechanistic Evidence Supporting a PoD for MMS; Mechanistic Evidence Supporting a PoD for MNU; Concluding Remarks; References; Chapter 6. The Role of Endogenous Versus Exogenous DNA Damage in Risk Assessment; Abstract; Introduction; Aldehydes; Alkylating Agents; Oxidative Stress; Ionizing Radiation

Quantifying Complex Dose-Response Relationships to Support Risk AssessmentsConclusion; References; Chapter 7. Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals; Abstract; Introduction; Genotoxic and Nongenotoxic Carcinogens; Thresholds of Chemical Genotoxicity; Risk Management for Genotoxic Carcinogens; Risk Assessment and Control of Genotoxic Impurities in Pharmaceuticals; Conclusion; References; Chapter 8. Practical Thresholds in the Derivation of Occupational Exposure Limits (OELs) for Carcinogens; Abstract; Introduction

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